Hypoxia in astrocytic tumors and implications for therapy

被引：27

作者：

Cavazos, David A. ^{[1
]}

Brenner, Andrew J. ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA

来源：

NEUROBIOLOGY OF DISEASE | 2016年 / 85卷

基金：

美国国家卫生研究院;

关键词：

Glioblastoma multiforme; Astrocytic tumors; Hypoxia; Metabolic derangement; Aerobic glycolysis; TH-302; CXCL12; CXCR7; Pseudopalisading necrosis; Acetate; GROWTH IN-VIVO; CHEMOKINE RECEPTOR; HUMAN GLIOBLASTOMA; ACTIVATED PRODRUG; GLIOMA; CELLS; BEVACIZUMAB; METABOLISM; EXPRESSION; INVASION;

D O I：

10.1016/j.nbd.2015.06.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glioblastoma (GBM, Grade IV astrocytoma) is the most common and most aggressive of the primary malignant brain tumors in adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression, resistance to treatment and poor outcomes. This review considers the effects of hypoxia on astrocytic tumors and the mechanisms that contribute to tumor progression and therapeutic resistance, with a focus on the vascular changes, chemotaxic signaling pathways and metabolic alterations involved. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：227 / 233

页数：7

共 62 条

[1] Hypoxia Helps Glioma to Fight Therapy [J].

Amberger-Murphy, Verena .

CURRENT CANCER DRUG TARGETS, 2009, 9 (03) :381-390

[2] SDF-1α Secreted by Human CD133-Derived Multipotent Stromal Cells Promotes Neural Progenitor Cell Survival Through CXCR7 [J].

Bakondi, Benjamin ;

Shimada, Issei S. ;

Peterson, Brittni M. ;

Spees, Jeffrey L. .

STEM CELLS AND DEVELOPMENT, 2011, 20 (06) :1021-1029

[3] AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients [J].

Batchelor, Tracy T. ;

Sorensen, A. Gregory ;

di Tomaso, Emmanuelle ;

Zhang, Wei-Ting ;

Duda, Dan G. ;

Cohen, Kenneth S. ;

Kozak, Kevin R. ;

Cahill, Daniel P. ;

Chen, Poe-Jou ;

Zhu, Mingwang ;

Ancukiewicz, Marek ;

Mrugala, Maciej M. ;

Plotkin, Scott ;

Drappatz, Jan ;

Louis, David N. ;

Ivy, Percy ;

Scadden, David T. ;

Benner, Thomas ;

Loeffler, Jay S. ;

Wen, Patrick Y. ;

Jain, Rakesh K. .

CANCER CELL, 2007, 11 (01) :83-95

[4] LIPID METABOLISM IMPAIRMENT IN HUMAN GLIOMAS: EXPRESSION OF PEROXISOMAL PROTEINS IN HUMAN GLIOMAS AT DIFFERENT GRADES OF MALIGNANCY [J].

Benedetti, E. ;

Galzio, R. ;

Laurenti, G. ;

D'Angelo, B. ;

Melchiorre, E. ;

Cifone, M. G. ;

Fanelli, F. ;

Muzi, P. ;

Coletti, G. ;

Alecci, M. ;

Sotgiu, A. ;

Ceru, M. P. ;

Cimini, A. .

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 2010, 23 (01) :235-246

[5] Contribution of CXCL12 secretion to invasion of breast cancer cells [J].

Boimel, Pamela J. ;

Smirnova, Tatiana ;

Zhou, Zhen Ni ;

Wyckoff, Jeffrey ;

Park, Haein ;

Coniglio, Salvatore J. ;

Qian, Bin-Zhi ;

Stanley, E. Richard ;

Cox, Dianne ;

Pollard, Jeffrey W. ;

Muller, William J. ;

Condeelis, John ;

Segall, Jeffrey E. .

BREAST CANCER RESEARCH, 2012, 14 (01)

[6] Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population [J].

Brat, DJ ;

Castellano-Sanchez, AA ;

Hunter, SB ;

Pecot, M ;

Cohen, C ;

Hammond, EH ;

Devi, SN ;

Kaur, B ;

Van Meir, EG .

CANCER RESEARCH, 2004, 64 (03) :920-927

[7]

Brenner A.J., 2014, NEUROONCOL, V16, pS5

[8]

BURGER PC, 1987, CANCER-AM CANCER SOC, V59, P1617, DOI 10.1002/1097-0142(19870501)59:9<1617::AID-CNCR2820590916>3.0.CO

[9]

2-X

[10] Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases [J].

Cartier, L ;

Hartley, O ;

Dubois-Dauphin, M ;

Krause, KH .

BRAIN RESEARCH REVIEWS, 2005, 48 (01) :16-42

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