Interspecies transmission and host restriction of avian H5N1 influenza virus

被引：29

作者：

Liu Di ^{[1
]}

Liu XiaoLing ^{[1
]}

Yan JingHua ^{[1
]}

Liu Wen-Jun ^{[1
]}

Gao George Fu ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China

来源：

SCIENCE IN CHINA SERIES C-LIFE SCIENCES | 2009年 / 52卷 / 05期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

H5N1 influenza virus; interspecies transmission; virus adaptation; host factors; MESSENGER-RNA TRANSLATION; SINGLE AMINO-ACID; A VIRUS; NS1; PROTEIN; RECEPTOR SPECIFICITY; NUCLEAR EXPORT; POLYMERASE COMPLEX; MATRIX PROTEIN; CELLULAR-PROTEIN; MOLECULAR-BASIS;

D O I：

10.1007/s11427-009-0062-z

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Long-term endemicity of avian H5N1 influenza virus in poultry and continuous sporadic human infections in several countries has raised the concern of another potential pandemic influenza. Suspicion of the avian origin of the previous pandemics results in the close investigation of the mechanism of interspecies transmission. Entry and fusion is the first step for the H5N1 influenza virus to get into the host cells affecting the host ranges. Therefore receptor usage study has been a major focus for the last few years. We now know the difference of the sialic acid structures and distributions in different species, even in the different parts of the same host. Many host factors interacting with the influenza virus component proteins have been identified and their role in the host range expansion and interspecies transmission is under detailed scrutiny. Here we review current progress in the receptor usage and host factors.

引用

页码：428 / 438

页数：11

共 105 条

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