Effects of Chronic Fluoxetine Treatment on Catalepsy and Immune Response in Mice Genetically Predisposed to Freezing Reaction: the Role of 5-HT1A and 5-HT2A Receptors and Tph2 and SERT Genes

被引：0
作者：
Tikhonova, M. A. [1 ]
Alperina, E. L.
Tolstikova, T. G.
Bazovkina, D. V.
Dee, V. Yu.
Idova, G. V.
Kulikov, A. V.
Popova, N. K.
机构：
[1] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia
来源：
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA | 2009年 / 59卷 / 02期
关键词：
fluoxetine; catalepsy; immune response; 5-HT1A receptors; 5-HT2A receptors; tryptophan hydroxylase-2; serotonin transporter; depressive-like state; SEROTONIN TRANSPORTER; BRAIN-SEROTONIN; MESSENGER-RNA; EXPRESSION; ASSAY; MODEL;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
ASC/Icg (Antidepressant Sensitive Catalepsy) mouse strain selected for high predisposition to pinch-induced catalepsy is characterized by depressive-like behavior and impaired immune response. Chronic treatment with SSRI fluoxetine attenuated catalepsy manifestation and normalized a decreased number of rosette-forming cells (RFC) in spleen in ASC mice. Chronic fluoxetine administration had no effect on catalepsy and RFC number in mice of parental cataleptic CBA/Lac strain. Fluoxetine failed to alter 5-HT1A receptor functional activity in mice of both strains and diminished 5-HT2A receptor functional activity in CBA but not in ASC mice. No effect on cortical 5-HT1A and 5-HT2A receptor mRNA levels and on 5-HT1A receptor, tph2 (tryptophan hydroxylase-2) and SERT (serotonin transporter) mesencephalic gene expression was observed in ASC mice. Other possible serotonergic mechanisms of fluoxetine effect on catalepsy and immune response in mice with depressive-like state are discussed.
引用
收藏
页码：237 / 244
页数：8
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