Modeling Adipogenesis: Current and Future Perspective

被引：55
作者：
Bahmad, Hisham F. [1 ]
Daouk, Reem [1 ]
Azar, Joseph [1 ]
Sapudom, Jiranuwat [2 ]
Teo, Jeremy C. M. [2 ]
Abou-Kheir, Wassim [1 ]
Al-Sayegh, Mohamed [3 ]
机构：
[1] Amer Univ Beirut, Dept Anat Cell Biol & Physiol Sci, Fac Med, Beirut 11072260, Lebanon
[2] New York Univ Abu Dhabi, Div Engn, Lab Immuno Bioengn Res & Applicat, Abu Dhabi 2460, U Arab Emirates
[3] New York Univ Abu Dhabi, Div Biol, Abu Dhabi 2460, U Arab Emirates
来源：
CELLS | 2020年 / 9卷 / 10期
关键词：
adipogenesis; preadipocytes; adipose-derived stem cells; organoids; modeling; PLURIPOTENT STEM-CELLS; ADIPOSE-TISSUE; ADIPOCYTE DIFFERENTIATION; INHIBITS ADIPOGENESIS; STROMAL CELLS; 3T3-L1; CELLS; PPAR-GAMMA; INSULIN; EXPRESSION; MOUSE;
D O I：
10.3390/cells9102326
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Adipose tissue is contemplated as a dynamic organ that plays key roles in the human body. Adipogenesis is the process by which adipocytes develop from adipose-derived stem cells to form the adipose tissue. Adipose-derived stem cells' differentiation serves well beyond the simple goal of producing new adipocytes. Indeed, with the current immense biotechnological advances, the most critical role of adipose-derived stem cells remains their tremendous potential in the field of regenerative medicine. This review focuses on examining the physiological importance of adipogenesis, the current approaches that are employed to model this tightly controlled phenomenon, and the crucial role of adipogenesis in elucidating the pathophysiology and potential treatment modalities of human diseases. The future of adipogenesis is centered around its crucial role in regenerative and personalized medicine.
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页数：21
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