White matter connectivity reflects clinical and cognitive status in Huntington's disease

被引：75
作者：
Poudel, Govinda R. [1 ,2 ,5 ]
Stout, Julie C. [1 ]
Dominguez D, Juan F. [1 ]
Salmon, Louisa [1 ]
Churchyard, Andrew [3 ]
Chua, Phyllis [1 ]
Georgiou-Karistianis, Nellie [1 ]
Egan, Gary F. [1 ,2 ,4 ,5 ]
机构：
[1] Monash Univ, Sch Psychol Sci, Clayton, Vic 3800, Australia
[2] Monash Univ, Monash Biomed Imaging MBI, Melbourne, Vic 3004, Australia
[3] Monash Med Ctr, Dept Neurol, Clayton, Vic 3168, Australia
[4] Univ Melbourne, Ctr Neurosci, Parkville, Vic 3052, Australia
[5] VLSCI Life Sci Computat Ctr, Melbourne, Vic, Australia
来源：
NEUROBIOLOGY OF DISEASE | 2014年 / 65卷
基金：
英国医学研究理事会;
关键词：
fMRI; Huntington's disease; Connectivity; Tractography; Diffusion tensor imaging; CORPUS-CALLOSUM; SPINY NEURONS; BASAL GANGLIA; CELL LOSS; MICROSTRUCTURE; ATROPHY; BRAIN; MOTOR; AGE;
D O I：
10.1016/j.nbd.2014.01.013
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Objective: To investigate structural connectivity and the relationship between axonal microstructure and clinical, cognitive, and motor functions in premanifest (pre-HD) and symptomatic (symp-HD) Huntington's disease. Method: Diffusion tensor imaging (DTI) data were acquired from 35 pre-HD, 36 symp-HD, and 35 controls. Structural connectivity was mapped between 40 brain regions of interest using tractography. Between-group differences in structural connectivity were identified using network based statistics. Radial diffusivity (RD) and fractional anisotropy (FA) were compared in the white matter tracts from aberrant networks. RD values in aberrant tracts were correlated with clinical severity, and cognitive and motor performance. Results: A network connecting putamen with prefrontal and motor cortex demonstrated significantly reduced tractography streamlines in pre-HD. Symp-HD individuals showed reduced streamlines in a network connecting prefrontal, motor, and parietal cortices with both caudate and putamen. The symp-HD group, compared to controls and pre-HD, showed both increased RD and decreased FA in the fronto-parietal and caudate-paracentral tracts and increased RD in the putamen-prefrontal and putamen-motor tracts. The pre-HDclose, compared to controls, showed increased RD in the putamen-prefrontal and fronto-parietal tracts. In the pre-HD group, significant negative correlations were observed between SDMT and Stroop performance and RD in the bilateral putamen-prefrontal tract In the symp-HD group, RD in the fronto-parietal tract was significantly positively correlated with UHDRS motor scores and significantly negatively correlated with performance on SDMT and Stroop tasks. Conclusions: We have provided evidence of aberrant connectivity and microstructural integrity in white matter networks in HD. Microstructural changes in the cortico-striatal fibers were associated with cognitive and motor performance in pre-HD, suggesting that changes in axonal integrity provide an early marker for clinically relevant impairment in HD. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：180 / 187
页数：8
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