Heteroarene-tethered Functionalized Alkyne Metamorphosis

被引：22

作者：

Bag, Debojyoti ^{[1
]}

Sawant, Sanghapal D. ^{[1
]}

机构：

[1] CSIR Indian Inst Integrat Med, Lab 212, Div Med Chem, Jammu 180001, Jammu & Kashmir, India

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2021年 / 27卷 / 04期

关键词：

alkynes; cycloisomerization; functionalization; heteroarene; metamorphosis; GOLD-CATALYZED SYNTHESIS; UGI INTRAMOLECULAR HYDROARYLATION; GARRATT-BRAVERMAN CYCLIZATION; CONTAINING NATURAL-PRODUCTS; ASYMMETRIC TOTAL-SYNTHESIS; VERSATILE BUILDING-BLOCKS; PROMOTED TANDEM REACTION; FORMAL TOTAL-SYNTHESIS; DIELS-ALDER REACTION; CARBON SIGMA-BONDS;

D O I：

10.1002/chem.202002154

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Heteroarene-tethered functionalized alkynes are multipotent synthons in organic chemistry. This detailed Review described herein offers a thorough discussion of the metamorphosis of heteroarene-tethered functionalized alkynes, an area which has earned much attention over the past decade in the straightforward synthesis of architecturally complex heterocyclic scaffolds in atom and step economic manner. Depending upon the variety of functionalized alkynes, this Review is divided into multiple sections. Amongst the vast array of synthetic transformations covered, dearomatizing spirocyclizations and cascade spirocyclization/rearrangement are of great interest. Synthetic transformations involving the heteroarene-tethered functionalized alkynes with scope, challenges, limitations, mechanism, their application in the total synthesis of natural products and future perceptions are surveyed.

引用

页码：1165 / 1218

页数：54

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