APOH interacts with FTO to predispose to healthy thinness

被引：6

作者：

Hasstedt, Sandra J. ^{[1
]}

Coon, Hilary ^{[2
]}

Xin, Yuanpei ^{[3
]}

Adams, Ted D. ^{[3
]}

Hunt, Steven C. ^{[3
,4
]}

机构：

[1] Univ Utah, Sch Med, Dept Human Genet, Salt Lake City, UT 84112 USA

[2] Univ Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84112 USA

[3] Univ Utah, Sch Med, Cardiovasc Genet Div, Salt Lake City, UT 84112 USA

[4] Weill Cornell, Coll Med, Dept Med Genet, Doha, Qatar

来源：

HUMAN GENETICS | 2016年 / 135卷 / 02期

基金：

美国国家卫生研究院;

关键词：

KERNEL ASSOCIATION TEST; GENE; PLASMA; IDENTIFICATION; METAANALYSIS; PEDIGREES; OBESITY; JPAP; TOOL;

D O I：

10.1007/s00439-015-1629-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We identified eight candidate thinness predisposition variants from the Illumina HumanExome chip genotyped on members of pedigrees selected for either healthy thinness or severe obesity. For validation, we tested the candidates for association with healthy thinness in additional pedigree members while accounting for effects of obesity-associated genes: NPFFR2, NPY2R, FTO, and MC4R. Significance was obtained for the interaction of FTO rs9939609 with APOH missense variant rs52797880 (minor allele frequency 0.054). The thinness odds ratio was estimated as 2.15 (p < 0.05) for the combination of APOH heterozygote with the homozygote for the non-obesity FTO allele. Significance was not obtained for any other combination of a candidate variant with an obesity gene or for any of the eight candidates tested independently.

引用

页码：201 / 207

页数：7

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