Renoprotective effect of tectorigenin glycosides isolated from Iris spuria L. (Zeal) against hyperoxaluria and hyperglycemia in NRK-49Fcells

被引：7

作者：

Divya, Ganesan ^{[1
]}

Albert, Abhishek ^{[1
]}

Singab, Abdel Nasser B. ^{[2
]}

Ayoub, Iriny M. ^{[2
]}

Al-Sayed, Eman ^{[2
]}

Paul, Eldho ^{[1
]}

Manoharan, Kumarriah ^{[3
]}

Saso, Luciano ^{[4
]}

Selvam, Govindan Sadasivam ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Sch Biol Sci, Dept Biochem, Madurai, Tamil Nadu, India

[2] Ain Shams Univ, Fac Pharm, Dept Pharmacognosy, Cairo, Egypt

[3] Madurai Kamaraj Univ, Sch Biol Sci, Dept Plant Sci, Madurai, Tamil Nadu, India

[4] Sapienza Univ, Dept Physiol & Pharmacol Vittorio Erspamer, Rome, Italy

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 06期

关键词：

Iris spuria L; tectorigenin derivatives; antioxidant; oxalate; hyperglycemia; hyperoxaluria;

D O I：

10.1080/14786419.2019.1613396

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Oxidative stress has been identified as an underlying factor in the development of insulin resistance, beta-cell dysfunction, impaired glucose tolerance and type 2 diabetes mellitus and it also play major role in kidney stone formation. The present study is aimed to elucidate the in vitro nephroprotective activity of two isoflavonoid glycosides, tectorigenin 7-O-beta-D-glucosyl-(1 -> 6)-beta-D-glucoside (1) and tectorigenin 7-O-beta-D-glucosyl-4 '-O-beta-D-glucoside (2) isolated from the n-BuOH fraction of Iris spuria L. (Zeal) rhizome MeOH extract against oxalate and high glucose-induced oxidative stress in NRK-49F cells. The results revealed that compounds 1 and 2 significantly increased the antioxidant enzyme activities and decreased MDA levels in both oxalate and high glucose stress. Treatment with these phytochemicals effectively down-regulated expression of crystal modulator genes and pro-fibrotic genes in oxalate and high glucose-mediated stress respectively. This study indicates cytoprotective, antioxidant, anti-urolithic and anti-diabetic effects of compounds 1 and 2 against oxalate and high glucose stress.

引用

页码：1029 / 1034

页数：6