Extracellular stability of nanoparticulate drug carriers

被引：19
作者：
Liu, Karen C. [1 ]
Yeo, Yoon [1 ,2 ,3 ]
机构：
[1] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA
[2] Purdue Univ, Dept Ind & Phys Pharm, W Lafayette, IN 47907 USA
[3] Korea Inst Sci & Technol, Biomed Res Inst, Seoul 136791, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2014年 / 37卷 / 01期
基金：
美国国家科学基金会;
关键词：
Nanomedicine; Nanoparticles; Drug delivery; Stability; Sensitivity; POLYMERIC MICELLE; BLOCK-COPOLYMER; PHASE-I; PACLITAXEL; TUMOR; CANCER; PH; DELIVERY; ALBUMIN; FORMULATION;
D O I：
10.1007/s12272-013-0286-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nanoparticulate (NP) drug carrier systems are attractive vehicles for selective drug delivery to solid tumors. Ideally, NPs should evade clearance by the reticuloendothelial system while maintaining the ability to interact with tumor cells and facilitate cellular uptake. Great effort has been made to fulfill these design criteria, yielding various types of functionalized NPs. Another important consideration in NP design is the physical and functional stability during circulation, which, if ignored, can significantly undermine the promise of intelligently designed NP drug carriers. This commentary reviews several NP examples with stability issues and their consequences, ending in a discussion of experimental methods for reliable prediction of NP stability.
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收藏
页码：16 / 23
页数：8
相关论文
共 32 条
  • [1] Low Molecular-Weight Chitosan as a pH-Sensitive Stealth Coating for Tumor-Specific Drug Delivery
    Amoozgar, Zohreh
    Park, Joonyoung
    Lin, Qingnuo
    Yeo, Yoon
    [J]. MOLECULAR PHARMACEUTICS, 2012, 9 (05) : 1262 - 1270
  • [2] Hyaluronic acid-based hydrogel for regional delivery of paclitaxel to intraperitoneal tumors
    Bajaj, Gaurav
    Kim, Mi Ran
    Mohammed, Sulma I.
    Yeo, Yoon
    [J]. JOURNAL OF CONTROLLED RELEASE, 2012, 158 (03) : 386 - 392
  • [3] Development of copolymers of poly(D,L-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel
    Burt, HM
    Zhang, XC
    Toleikis, P
    Embree, L
    Hunter, WL
    [J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 1999, 16 (1-4) : 161 - 171
  • [4] Release of hydrophobic molecules from polymer micelles into cell membranes revealed by Forster resonance energy transfer imaging
    Chen, Hongtao
    Kim, Sungwon
    Li, Li
    Wang, Shuyi
    Park, Kinam
    Cheng, Ji-Xin
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (18) : 6596 - 6601
  • [5] Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo Forster resonance energy transfer imaging
    Chen, Hongtao
    Kim, Sungwon
    He, Wei
    Wang, Haifeng
    Low, Philip S.
    Park, Kinam
    Cheng, Ji-Xin
    [J]. LANGMUIR, 2008, 24 (10) : 5213 - 5217
  • [6] Nanoparticle Characterization: State of the Art, Challenges, and Emerging Technologies
    Cho, Eun Jung
    Holback, Hillary
    Liu, Karen C.
    Abouelmagd, Sara A.
    Park, Joonyoung
    Yeo, Yoon
    [J]. MOLECULAR PHARMACEUTICS, 2013, 10 (06) : 2093 - 2110
  • [7] Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: An in vivo proof-of-concept study
    de Smet, Mariska
    Heijman, Edwin
    Langereis, Sander
    Hijnen, Nicole M.
    Grull, Holger
    [J]. JOURNAL OF CONTROLLED RELEASE, 2011, 150 (01) : 102 - 110
  • [8] Desai N., 2007, Drug Delivery Report, V16th, P37
  • [9] A docetaxel-carboxymethylcellulose nanoparticle outperforms the approved taxane nanoformulation, Abraxane, in mouse tumor models with significant control of metastases
    Ernsting, Mark J.
    Murakami, Mami
    Undzys, Elijus
    Aman, Ahmed
    Press, Barry
    Li, Shyh-Dar
    [J]. JOURNAL OF CONTROLLED RELEASE, 2012, 162 (03) : 575 - 581
  • [10] Gerweck LE, 1996, CANCER RES, V56, P1194
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