Helicobacter pylori and interleukin-8 in gastric cancer

被引：91

作者：

Lee, Ko Eun ^{[1
]}

Pham Ngoc Khoi ^{[1
]}

Xia, Yong ^{[1
]}

Park, Jung Sun ^{[1
]}

Joo, Young Eun ^{[1
]}

Kim, Kyung Keun ^{[1
]}

Choi, Seok Yong ^{[1
]}

Jung, Young Do ^{[1
]}

机构：

[1] Chonnam Natl Univ, Res Inst Med Sci, Sch Med, Kwangju 501190, South Korea

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2013年 / 19卷 / 45期

基金：

新加坡国家研究基金会;

关键词：

Helicobacter pylori; Interleukin-8; Signals; Gastric cancer; Therapeutics; NF-KAPPA-B; CONJUGATED LINOLEIC ACIDS; NECROSIS-FACTOR-ALPHA; EPITHELIAL-CELLS; INFLAMMATORY RESPONSE; GENE-EXPRESSION; MOLECULAR CHARACTERIZATION; PLASMINOGEN-ACTIVATOR; ATROPHIC GASTRITIS; ENDOTHELIAL-CELLS;

D O I：

10.3748/wjg.v19.i45.8192

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Helicobacter pylori (H. pylori) is a major etiological factor in the development of gastric cancer. Large-scale epidemiological studies have confirmed the strong association between H. pylori infection and both cancer development and progression. Interleukin-8 (IL-8) is overexpressed in gastric mucosa exposed to H. pylori. The expression of IL-8 directly correlates with a poor prognosis in gastric cancer. IL-8 is multifunctional. In addition to its potent chemotactic activity, it can induce proliferation and migration of cancer cells. In this review, we focus on recent insights into the mechanisms of IL-8 signaling associated with gastric cancer. The relationship between IL-8 and H. pylori is discussed. We also summarize the current therapeutics against IL-8 in gastric cancer. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.

引用

页码：8192 / 8202

页数：11

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