Compassionate use of tocilizumab in severe SARS-CoV2 pneumonia

被引：6

作者：

Gorgolas Hernandez-Mora, Miguel ^{[1
]}

Cabello Ubeda, Alfonso ^{[1
]}

Prieto-Perez, Laura ^{[1
]}

Villar Alvarez, Felipe ^{[2
]}

Alvarez Alvarez, Beatriz ^{[1
]}

Rodriguez Nieto, Maria Jesus ^{[2
]}

Carrillo Acosta, Irene ^{[1
]}

Fernandez Ormaechea, Itziar ^{[2
]}

Mohammed Al-Hayani, Aws Waleed ^{[1
]}

Carballosa, Pilar ^{[2
]}

Calpena Martinez, Silvia ^{[1
]}

Ezzine, Farah ^{[2
]}

Castellanos Gonzalez, Marina ^{[1
]}

Naya, Alba ^{[2
]}

Lopez Heras, Marta ^{[1
]}

Rodriguez Guzman, Marcel Jose ^{[2
]}

Cordero Guijarro, Ana ^{[4
]}

Broncano Lavado, Antonio ^{[3
]}

Macias Valcayo, Alicia ^{[3
]}

Martin Garcia, Marta ^{[3
]}

Becares Martinez, Javier ^{[4
]}

Fernandez Roblas, Ricardo ^{[3
]}

Piris Pinilla, Miguel Angel ^{[5
]}

Fortes Alen, Jose ^{[5
]}

Sanchez Pernaute, Olga ^{[6
]}

Romero Bueno, Fredeswinda ^{[6
]}

Heili-Frades, Sarah ^{[2
]}

Peces-Barba Romero, German ^{[2
]}

机构：

[1] Univ Autonoma Madrid, Fdn Jimenez Diaz, Div Infect Dis, Madrid, Spain

[2] Univ Autonoma Madrid, Fdn Jimenez Diaz, Dept Pneumol, Madrid, Spain

[3] Univ Autonoma Madrid, Fdn Jimenez Diaz, Dept Microbiol, Madrid, Spain

[4] Fdn Jimenez Diaz, Dept Pharm, Madrid, Spain

[5] Univ Autonoma Madrid, Fdn Jimenez Diaz, Dept Pathol, Madrid, Spain

[6] Univ Autonoma Madrid, Fdn Jimenez Diaz, Dept Rheumatol, Madrid, Spain

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2021年 / 102卷

关键词：

SARS-CoV-2; Covid-19; Tocilizumab; Pneumonia; Treatment; CYTOKINE STORM; MULTICENTER; COVID-19; EFFICACY;

D O I：

10.1016/j.ijid.2020.10.045

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Introduction: Tocilizumab (TCZ) is an interleukin-6 receptor antagonist, which has been used for the treatment of severe SARS-CoV-2 pneumonia (SSP), which aims to ameliorate the cytokine release syndrome (CRS) induced acute respiratory distress syndrome (ARDS). However, there are no consistent data about who might benefit most from it. Methods: We administered TCZ on a compassionate-use basis to patients with SSP who were hospitalized (excluding intensive care and intubated cases) and who required oxygen support to have a saturation 0.001) in those receiving the drug when the oxygen support was high (FiO2 0.5%). Conclusions: TCZ is well tolerated in patients with SSP, but it has a limited effect on the evolution of cases with high oxygen support needs. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：303 / 309

页数：7

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