Manganese oxide/Metal-Organic Frameworks-Based Nanocomposites for Tumr Micro-environment Sensitive 1H/19F Dual-mode Magnetic Resonance Imaging in Vivo

被引：13
作者：
Zhou, Han [1 ,2 ]
Qi, Ming [3 ]
Shao, Jing [1 ,2 ]
Wang, Fengsheng [1 ,2 ]
Li, Xiaoling [1 ,2 ]
Zhou, Zhiguo [1 ,2 ]
Yang, Shiping [1 ,2 ]
Yang, Hong [1 ,2 ,4 ]
机构：
[1] Minist Educ, Shanghai Key Lab Rare Earth Funct Mat, Key Lab Resource Chem, Shanghai 200234, Peoples R China
[2] Shanghai Normal Univ, Shanghai 200234, Peoples R China
[3] Fudan Univ, Key Lab Nucl Phys & Ion Beam Applicat MOE, Inst Modern Phys, Dept Nucl Sci & Technol, Shanghai 200433, Peoples R China
[4] Nanjing Univ Posts & Telecommun, Inst Adv Mat IAM, Jiangsu Key Lab Biosensors, 9 Wenyuan Rd, Nanjing 210023, Peoples R China
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2021年 / 933卷
基金：
中国国家自然科学基金;
关键词：
Metal-organic Framework; Nanoprobe; Dual-mode MRI; GSH response; pH response; MESOPOROUS SILICA NANOPARTICLES; FUNCTIONALIZATION; PLATFORM; PROBES; MOFS; MNO2;
D O I：
10.1016/j.jorganchem.2020.121652
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A pH- and GSH-responsive H-1/F-19 dual-mode magnetic resonance imaging contrast agent (MRI CA) was constructed by incorporating MnOx into Zr-based MOF nanoparticles (MnOx/UiO-66-F/PPEG NPs) with an organic ligand of tetrafluoro-terephthalic acid (F(4)PTA). Under a weak acidic tumor micro-environment, MnOx/UiO-66-F/PPEG NPs would collapse to release MnOx and free F(4)PTA. Due to the released free F(4)PTA, F-19 MRI signal was enhanced. Meanwhile, GSH, which is overexpressed in a tumor micro-environment, reduced MnOx to divalent manganese ions and improved the T-1-weighted MR imaging capability. As a proof of concept, MnOx/UiO-66-F/PPEG NPs was favorable for dual H-1/F-19 MRI with a high signal-to-noise ratio in vivo. (C) 2020 Published by Elsevier B.V.
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页数：4
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