Inhibition of secretion of interleukin-1α and tumor necrosis factor alpha by the ketolide antibiotic telithromycin

被引：26
作者：
Araujo, FG
Slifer, TL
Remington, JS
机构：
[1] Palo Alto Med Fdn, Res Inst, Palo Alto, CA 94301 USA
[2] Stanford Univ, Sch Med, Palo Alto, CA 94301 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 10期
关键词：
D O I：
10.1128/AAC.46.10.3327-3330.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The antibiotic telithromycin was examined for its effect on secretion of interleukin-1alpha (IL-1alpha), IL-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNF-alpha) by lipopolysaccharide (LPS)-stimulated monocytes of eight human donors. Secretion of each cytokine was significantly increased by LPS alone, whereas treatment with telithromycin significantly inhibited secretion of IL-1alpha and TNF-alpha but not secretion of IL-1beta, IL-6, and IL-10. Telithromycin had immunomodulatory effects as a result of alteration of secretion of IL-1alpha and TNF-alpha by monocytes.
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收藏
页码：3327 / 3330
页数：4
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