Infrared imaging microscopy of bone: Illustrations from a mouse model of Fabry disease

被引：19

作者：

Boskey, Adele L. ^{[1
]}

Goldberg, Michel

Kulkarni, Ashok

Gomez, Santiago

机构：

[1] Univ Paris 05, Fac Chirurg Dent, Grp Matrice Extracellulaires & Biomineralisat, EA 4296,Lab Reparat & Remodelage Tissus Oro Facia, Montrouge, France

[2] Cornell Univ, Hosp Special Surg, Ithaca, NY 14853 USA

[3] Cornell Univ, Weill Med Coll, Ithaca, NY 14853 USA

[4] Natl Inst Dent & Craniofacial Res, Funct Genom Sect, Craniofacial Dev & Regenerat Biol Branch, NIH, Bethesda, MD 20892 USA

[5] Univ Cadiz, Dept Anat Patol, Cadiz, Spain

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2006年 / 1758卷 / 07期

关键词：

infrared microscopic imaging; bone; hydroxyapatite; Fabry disease;

D O I：

10.1016/j.bbamem.2006.02.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone is a complex tissue whose composition and properties vary with age, sex, diet, tissue type, health and disease. In this review, we demonstrate how infrared spectroscopy and infrared spectroscopic imaging can be applied to the study of these variations. A specific example of mice with Fabry disease (a lipid storage disease) is presented in which it is demonstrated that the bones of these young animals, while showing typical spatial variation in mineral content, mineral crystal size, and collagen maturity, do not differ from the bones of age- and sex-matched wild type animals. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：942 / 947

页数：6

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