Formal [3+2] cycloaddition of 1-cyanocyclopropane 1-ester with pyridine, quinoline or isoquinoline: a general and efficient strategy for construction of cyanoindolizine skeletons

被引：64

作者：

Liu, Juanjuan ^{[1
]}

Zhou, Lanxiang ^{[1
]}

Ye, Weijian ^{[1
]}

Wang, Cunde ^{[1
]}

机构：

[1] Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225002, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 65期

基金：

中国国家自然科学基金;

关键词：

CARBONYL-COMPOUNDS; ANNULATION; CYCLOPROPANES; DERIVATIVES; INDOLIZINES; YLIDES; AMINOCYCLOPROPANES; ACTIVATION; INHIBITORS; ALDEHYDES;

D O I：

10.1039/c4cc03267e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and straightforward synthetic protocol has been developed for the preparation of cyanoindolizine derivatives via a cycloaddition reaction between 1-cyanocyclopropane 1-ester and pyridine or benzo-pyridine for the generation of a wide range of structurally interesting and pharmacologically significant compounds.

引用

页码：9068 / 9071

页数：4

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