Developing Microphysiological Systems for Use as Regulatory Tools - Challenges and Opportunities

被引:28
作者
Andersen, Melvin E. [1 ]
Betts, Kellyn
Dragan, Yvonne [2 ]
Fitzpatrick, Suzanne [3 ]
Goodman, Jesse L. [4 ]
Hartung, Thomas [5 ]
Himmelfarb, Jonathan [6 ]
Ingber, Donald E. [7 ]
Jacobs, Abigail [8 ]
Kavlock, Robert [9 ]
Kolaja, Kyle [10 ]
Stevens, James L. [11 ]
Tagle, Dan [12 ]
Taylor, D. Lansing [13 ]
Throckmorton, Douglas [8 ]
机构
[1] Hamner Inst Hlth Sci, Res Triangle Pk, NC USA
[2] AstraZeneca, Waltham, MA USA
[3] US FDA, Ctr Food Safety & Appl Nutr, Silver Spring, MD USA
[4] US FDA, Silver Spring, MD USA
[5] Johns Hopkins Univ, Ctr Alternat Anim Testing, Baltimore, MD USA
[6] Univ Washington, Kidney Res Inst, Seattle, WA USA
[7] Harvard Univ, Wyss Inst Biol Inspired Engn, Cambridge, MA 02138 USA
[8] US FDA, Ctr Drug Evaluat & Res, Silver Spring, MD USA
[9] US EPA, Res Triangle Pk, NC USA
[10] Cellular Dynamics Int Inc, Madison, WI USA
[11] Lilly Res Labs, Greenfield, IN 46140 USA
[12] Natl Ctr Adv Translat Sci, NIH, Bethesda, MD USA
[13] Univ Pittsburgh, Drug Discovery Inst, Pittsburgh, PA USA
关键词
CHIP;
D O I
10.14573/altex.1405151
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:364 / 367
页数:4
相关论文
共 6 条
[1]   Phase II failures: 2008-2010 [J].
Arrowsmith, John .
NATURE REVIEWS DRUG DISCOVERY, 2011, 10 (05) :1-1
[2]   A Human Disease Model of Drug Toxicity-Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice [J].
Huh, Dongeun ;
Leslie, Daniel C. ;
Matthews, Benjamin D. ;
Fraser, Jacob P. ;
Jurek, Samuel ;
Hamilton, Geraldine A. ;
Thorneloe, Kevin S. ;
McAlexander, Michael Allen ;
Ingber, Donald E. .
SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (159)
[3]   Reconstituting Organ-Level Lung Functions on a Chip [J].
Huh, Dongeun ;
Matthews, Benjamin D. ;
Mammoto, Akiko ;
Montoya-Zavala, Martin ;
Hsin, Hong Yuan ;
Ingber, Donald E. .
SCIENCE, 2010, 328 (5986) :1662-1668
[4]   Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation [J].
Kim, Hyun Jung ;
Ingber, Donald E. .
INTEGRATIVE BIOLOGY, 2013, 5 (09) :1130-1140
[5]   Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow [J].
Kim, Hyun Jung ;
Huh, Dongeun ;
Hamilton, Geraldine ;
Ingber, Donald E. .
LAB ON A CHIP, 2012, 12 (12) :2165-2174
[6]   Can the pharmaceutical industry reduce attrition rates? [J].
Kola, I ;
Landis, J .
NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (08) :711-715