Development and physico-chemical characterization of cyclodextrin-DNA complexes loaded liposomes

被引：16
|
作者：
Tavares, Guilherme D.
Viana, Cristiane M.
Araujo, Jose G. V. C.
Ramaldes, Gilson A.
Carvalho, Wania S.
Pesquero, Jorge L.
Vilela, Jose M. C.
Andrade, Margareth S.
de Oliveira, Monica C.
机构：
[1] Univ Fed Minas Gerais, Lab Farmacotecn & Tecnol Farmaceut, Dept Prod Farmaceut, Fac Farm, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Lab Biofis, Dept Fisiol & Biofis, Inst Ciencias Biol, BR-31270901 Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Lab Biol Mol, Dept Farm Social, Fac Farm, BR-31270901 Belo Horizonte, MG, Brazil
[4] Fdn Ctr Tecnol Minas Gerias, Lab Nanoscopia, BR-31170000 Belo Horizonte, MG, Brazil
来源：
CHEMICAL PHYSICS LETTERS | 2006年 / 429卷 / 4-6期
关键词：
D O I：
10.1016/j.cplett.2006.08.043
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In the present study, anionic and pH-sensitive liposomes containing DNA were developed and characterized. These liposomes were obtained by binding the DNA with 6-monodeoxy-6-monoamine-beta-cyclodextrin (Am-beta-CD). This complex was encapsulated into the liposomes, which were characterized by encapsulation rate, diameter, zeta potential, and atomic force microscopy. The binding between Am-beta-CD and the DNA was higher as of the +/- charge ratio. The amount of DNA encapsulated was approximately 10-14 mu g/mL. The mean diameter and zeta potential were 186.0 nm and -56 mV, respectively. Liposomes which did not contain the complex were more prone to collapse over the mica surface. The vesicles containing the complex presented a narrower size distribution. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：507 / 512
页数：6
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