Effects of Omega-3 Fatty Acids on Muscle Mass, Muscle Strength and Muscle Performance among the Elderly: A Meta-Analysis

被引:98
作者
Huang, Ya-Hui [1 ,2 ]
Chiu, Wan-Chun [3 ,4 ]
Hsu, Yuan-Pin [1 ,5 ]
Lo, Yen-Li [6 ]
Wang, Yuan-Hung [1 ,7 ]
机构
[1] Taipei Med Univ, Coll Med, Grad Inst Clin Med, Taipei 11031, Taiwan
[2] Taipei City Hosp, Dept Dietet & Nutr, Heping Fuyou Branch, Taipei 10065, Taiwan
[3] Taipei Med Univ, Coll Nutr, Sch Nutr & Hlth Sci, Taipei 11031, Taiwan
[4] Taipei Med Univ, Coll Nutr, Res Ctr Geriatr Nutr, Taipei 11031, Taiwan
[5] Taipei Med Univ, Wan Fang Hosp, Emergency Dept, Taipei 11696, Taiwan
[6] Natl Yang Ming Univ, Dept Biomed Engn, Taipei 11221, Taiwan
[7] Taipei Med Univ, Shuang Ho Hosp, Dept Med Res, New Taipei 23561, Taiwan
关键词
docosahexaenoic acid (DHA); elderly; eicosapentaenoic acid (EPA); omega-3 fatty acid; n-3; PUFAs; sarcopenia; POLYUNSATURATED FATTY-ACIDS; FISH-OIL SUPPLEMENTATION; OLDER-ADULTS; DOUBLE-BLIND; POSTMENOPAUSAL WOMEN; PHYSICAL PERFORMANCE; PROTEIN-METABOLISM; DIABETES RISK; SARCOPENIA; PREVENTION;
D O I
10.3390/nu12123739
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
There is increasing evidence showing the role of fatty acids and their derived lipid intermediates in the regulation of skeletal muscle mass synthesis and function. However, the role of omega-3 fatty acids remains unclear. Therefore, we conducted a meta-analysis to evaluate the potential effects of omega-3 fatty acids on sarcopenia-related performances among the elderly. Eligible literature and reports of randomized controlled trials were comprehensively searched from the PubMed, Cochrane Library, ClinicalTrials.gov, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases until July 2018. A total of 10 articles were available for the meta-analysis. There were minor benefits for muscle mass gain (0.33 kg; 95% CI: 0.05, 0.62) and timed up and go performance (-0.30 s; 95% CI: -0.43, -0.17). Subgroup analyses regarding muscle mass and walk speed indicated that omega-3 fatty acid supplements at more than 2 g/day may contribute to muscle mass gain (0.67 kg; 95% CI: 0.16, 1.18) and improve walking speed, especially for those receiving more than 6 months of intervention (1.78 m/sec; 95% CI: 1.38, 2.17). Our findings provide some insight into the effects of omega-3 fatty acids on muscle mass, especially for those taking supplements at more than 2 g/day. We also observed that a long period of omega-3 fatty acids supplementation may improve walking speed.
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页码:1 / 14
页数:14
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