Annonaceous acetogenins reverses drug resistance of human hepatocellular carcinoma BEL-7402/5-FU and HepG2/ADM cell lines

被引：1

作者：

Qian, Jun-Qiang ^{[1
]}

Sun, Pei ^{[1
]}

Pan, Zhan-Yu ^{[2
]}

Fang, Zhi-Zhong ^{[3
]}

机构：

[1] Tianjin Med Univ Canc Inst & Hosp, Dept Pharm, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin 300060, Peoples R China

[2] Tianjin Med Univ Canc Inst & Hosp, Dept Integrat Oncol, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin 300060, Peoples R China

[3] Tianjin Med Univ, Sch Pharm, Tianjin 300070, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 09期

关键词：

Annonaceous acetogenins; hepatocellular carcinoma; drug resistance; MULTIDRUG-RESISTANCE; GASTRIC-CANCER; EXPRESSION; PATHWAY; FAMILY;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is the most common tumor in worldwide and chemotherapy resistant is a severe obstacle in HCC treatment. Annonaceous acetogenins was a nature compound from Uvaria accuminata and it has show the anti-tumor proliferation activity in many types cancer. In this study, we showed that annonaceous acetogenins is correlated with the drug resistance reversal in human hepatocellular carcinoma BEL-7402/5-FU and HepG2/ADM cell lines. We found that cell apoptosis was improved and cell cycle was arrested, further, multidrug-resistance proteins such as MDR1, MRP1, Topo-II alpha, GST-pi, cyclin D1, Survivin and bcl-2 are down-regulated, however, intracellular Rh-123 and caspase-3/8 was up-regulated by Annonaceous acetogenins treatment. We also found that there was a decreased activity of NF-.B and Akt in Annonaceous acetogenins treatment groups. Therefore, we demonstrate that Akt/NF-kappa B pathway was involved in Annonaceous acetogenins reverses drug resistance of human hepatocellular carcinoma cells.

引用

页码：11934 / 11944

页数：11

共 28 条

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