Understanding and applying tyrosine biochemical diversity

被引：66

作者：

Jones, Lyn H. ^{[1
]}

Narayanan, Arjun ^{[1
]}

Hett, Erik C. ^{[1
]}

机构：

[1] Pfizer R&D, Chem Biol Grp, BioTherapeut Chem, WorldWide Med Chem, Cambridge, MA 02140 USA

来源：

MOLECULAR BIOSYSTEMS | 2014年 / 10卷 / 05期

关键词：

CYTOCHROME-C-OXIDASE; OXIDATIVE CROSS-LINKING; TUMOR-NECROSIS-FACTOR; APOLIPOPROTEIN-A-I; MANGANESE SUPEROXIDE-DISMUTASE; CYTOSOLIC 5'-NUCLEOTIDASE 1A; ACTIVE-SITE; CRYSTAL-STRUCTURE; ELECTRON-TRANSFER; MOLECULAR RECOGNITION;

D O I：

10.1039/c4mb00018h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review highlights some of the recent advances made in our understanding of the diversity of tyrosine biochemistry and shows how this has inspired novel applications in numerous areas of molecular design and synthesis, including chemical biology and bioconjugation. The pathophysiological implications of tyrosine biochemistry will be presented from a molecular perspective and the opportunities for therapeutic intervention explored.

引用

页码：952 / 969

页数：18

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