Blood flow regulation and oxidative stress during submaximal cycling exercise in patients with cystic fibrosis

被引：18

作者：

Tucker, Matthew A. ^{[1
]}

Berry, Breana ^{[1
]}

Seigler, Nichole ^{[1
]}

Davison, Gareth W. ^{[2
]}

Quindry, John C. ^{[3
]}

Eidson, Dabney ^{[4
]}

McKie, Kathleen T. ^{[4
]}

Harris, Ryan A. ^{[1
,2
]}

机构：

[1] Augusta Univ, Georgia Prevent Inst, Augusta, GA USA

[2] Ulster Univ, Sport & Exercise Sci Res Inst, Jordanstown, North Ireland

[3] Univ Montana, Dept Hlth & Human Performance, Missoula, MT 59812 USA

[4] Augusta Univ, Pediat Pulmonol, Augusta, GA USA

来源：

JOURNAL OF CYSTIC FIBROSIS | 2018年 / 17卷 / 02期

关键词：

Exercise intolerance; Reactive oxygen species; Retrograde velocity; Electron paramagnetic resonance spectroscopy; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION; OXYGEN-UPTAKE; FREE-RADICALS; RESPONSES; INTOLERANCE; HYPEREMIA; CAPACITY; CHILDREN;

D O I：

10.1016/j.jcf.2017.08.015

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: The impact of blood flow regulation and oxidative stress during exercise in cystic fibrosis (CF) has yet to be investigated. Methods: A maximal graded exercise test was conducted to determine exercise capacity (VO2 peak) and peak workload in 14 pediatric patients with mild CF (age 14 +/- 3 y, FEV1 93 +/- 16 % predicted) and 14 demographically-matched controls. On a separate visit, participants performed submaximal cycling up to 60% of peak workload where brachial artery blood velocity was determined using Doppler ultrasound. Retrograde and antegrade components were further analyzed as indices of blood flow regulation. Results: The cumulative AUC for retrograde velocity was lower in patients versus controls (1770 +/- 554 vs. 3440 +/- 522 cm, P = 0.038). In addition, an exaggerated oxidative stress response during exercise occurred in patients only (P = 0.004). Conclusion: These data suggest that patients with mild CF exhibit impaired blood flow regulation and an exaggerated oxidative stress response to submaximal exercise. (C) 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

引用

页码：256 / 263

页数：8

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