The prolyl isomerase Pin1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein and promotes malignant transformation

被引：39

作者：

Jeong, Soo-Jin ^{[1
]}

Ryo, Akihide ^{[1
]}

Yamamoto, Naoki ^{[1
]}

机构：

[1] Natl Inst Infect Dis, AIDS Res Ctr, Shinjuku Ku, Tokyo 1628640, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 381卷 / 02期

关键词：

Pin1; Tax; Protein stability; Ubiquitination; Transformation; I TAX; PROTEIN; UBIQUITINATION; DEGRADATION; INHIBITION; APOPTOSIS; P53;

D O I：

10.1016/j.bbrc.2009.02.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The HTLV Tax protein is Crucial for viral replication and malignant transformation. We investigated the possible role of peptidyl prolyl isomerase Pin1 in the positive regulation of the human T-cell leukemia virus type 1 Tax. Pin1 is highly expressed in adult T-cell leukemia (ATL) cells expressing Tax protein and forced expression of Pin1 in turn increases the Tax protein expression. Pin1 prolonged the protein half-life of Tax by suppressing the ubiquitination and subsequent lysosomal degradation of Tax. Pin1 interacts with phosphorylated Tax on its Ser160-Pro motif at the mitotic phase. Finally, we found that Pin1 plays a supporting role in Tax-mediated cell transformation. Our current study demonstrates an important role for Pin1 in the post-translational regulation of Tax and suggests that the targeting of Pin1 may offer a new insight into the pathogenesis of HTLV-I related diseases. (c) 2009 Elsevier Inc. All rights reserved.

引用

页码：294 / 299

页数：6

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