Increased Frequency of Tim-3 Expressing T Cells Is Associated with Symptomatic West Nile Virus Infection

被引：16

作者：

Lanteri, Marion C. ^{[1
]}

Diamond, Michael S. ^{[2
,3
,4
]}

Law, Jacqueline P. ^{[1
]}

Chew, Glen M. ^{[5
]}

Wu, Shiquan ^{[1
]}

Inglis, Heather C. ^{[1
]}

Wong, Derek ^{[1
]}

Busch, Michael P. ^{[1
,6
]}

Norris, Philip J. ^{[1
,6
,7
]}

Ndhlovu, Lishomwa C. ^{[5
]}

机构：

[1] Univ Calif San Francisco, Blood Syst Res Inst, San Francisco, CA 94143 USA

[2] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[5] Univ Hawaii, John A Burns Sch Med, Dept Trop Med, Honolulu, HI 96822 USA

[6] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA

[7] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

来源：

PLOS ONE | 2014年 / 9卷 / 03期

关键词：

BLOCKADE; EXHAUSTION; IMMUNITY; CD4(+);

D O I：

10.1371/journal.pone.0092134

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

More than a decade after West Nile virus (WNV) entered North America, and despite a significant increase in reported cases during the 2012 and 2013 seasons, no treatment or vaccine for humans is available. Although antiviral T cells contribute to the control of WNV, little is known about their regulation during acute infection. We analyzed the expression of Tim-3 and PD-1, two recently identified T cell negative immune checkpoint receptors, over the course of WNV infection. Symptomatic WNV+ donors exhibited higher frequencies of Tim-3(+) cells than asymptomatic subjects within naive/early differentiated CD28(+/-)CD57(-)CD4(+) and differentiated CD28(-)CD57(-)CD8(+) T cells. Our study links Tim-3-expression on T cells during acute WNV infection with the development of symptomatic disease, suggesting Tim-3 and its ligands could be targeted therapeutically to alter anti-WNV immunity and improve disease outcome.

引用

页数：11