Th1/Th2 polarization in tonsillar lymphocyte form patients with IgA nephropathy

被引：42

作者：

He, Liyu ^{[1
]}

Peng, Youming ^{[1
]}

Liu, Hong ^{[1
]}

Yin, Wenqing ^{[1
]}

Chen, Xian ^{[1
]}

Peng, Xiaofei ^{[1
]}

Shao, Jing ^{[1
]}

Liu, Yinghong ^{[1
]}

Liu, Fuyou ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp 2, Dept Nephrol, Key Lab Kidney Dis & Blood Purificat Hunan, Changsha 410011, Hunan, Peoples R China

来源：

RENAL FAILURE | 2014年 / 36卷 / 03期

基金：

中国国家自然科学基金;

关键词：

alpha-hemolytic streptococcus; IgA nephropathy; LPS; Th1/Th2; tonsillar lymphocyte; T-CELLS; CYTOKINE; GLYCOSYLATION; PATHOGENESIS; INDUCTION; NEPHRITIS; DISEASE;

D O I：

10.3109/0886022X.2013.862809

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Imbalance of Th1/Th2 pro-inflammatory cytokines plays an important role in the development and progression of IgA nephropathy (IgAN). Clinical development and exacerbation of IgAN are frequently preceded by episodes of upper respiratory tract infection, and palatine tonsils represent the predominant immunocompetent tissue of the upper respiratory tract. This study examined tonsillar lymphocytes of IgAN who suffered from tonsillitis (n = 22), and using tonsils derived from patients with chronic tonsillitis (n = 24) but without renal disease as a control. We identified a polarization toward Th2 response in tonsils of IgAN patients. TH0 cells are differentially mobilized during contact sensitization and by adjuvants such as lipopolysaccharide (LPS) that induce T-helper type 1 (Th1) responses, or a-hemolytic streptococcus (HS) that induces T-helper type 2 (Th2) responses. Th1: Th2 ratio is correlated with proteinuria and renal pathologic changes in IgAN group. Our study suggests that IgAN is associated with the change in Th1/Th2 balance in favor of Th2 lymphocytes.

引用

页码：407 / 412

页数：6

共 24 条

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