Covalent Capture of a Heterotrinneric Collagen Helix

被引：19

作者：

Li, I-Che ^{[1
]}

Hulgan, Sarah A. H. ^{[1
]}

Walker, Douglas R. ^{[1
]}

Farndale, Richard W. ^{[2
]}

Hartgerink, Jeffrey D. ^{[1
]}

Jalan, Abhishek A. ^{[3
]}

机构：

[1] Rice Univ, Dept Chem, 6100 Main St, Houston, TX 77005 USA

[2] Univ Cambridge, Dept Biochem, Downing Site, Cambridge CB2 1QW, England

[3] Univ Bayreuth, Dept Biochem, Univ Str 30, D-95447 Bayreuth, Germany

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 14期

关键词：

TRIPLE-HELIX; RATIONAL DESIGN; MIMETIC PEPTIDE; HIGH-STABILITY; HETEROTRIMERS; REGISTER; COMPLEMENT; MUTATIONS; BACTERIAL; RESIDUES;

D O I：

10.1021/acs.orglett.9b01771

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stabilizing the three-dimensional structure of supra molecular materials can be accomplished through covalent capture of the assembled system. The lysine-aspartate charge pairs designed to direct the self-assembly of a collagen triple helix were subsequently used to covalently capture the helix through proximity-directed amide bond formation using EDC/HOBT activation. The triple helix thus stabilized maintains its folded structure and can now be used for applications previously inaccessible due to problematic folding equilibria.

引用

页码：5480 / 5484

页数：5

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