The nano-particles system which is Thallium antimony telluride Tl10-xSbxTe6 with different doping with concentration of Sb (x = 1.00, 1.250, 1.500, 1.750, 2.00) were synthesized by solid state reaction method and then the nano-particles from the ingot by ball milling techniques. X-rays diffraction analysis has defined the phase purity of the system, as there is no extra peaks were observed. EDX spectroscopy result confirmed the elemental composition of Tl10-xSbxTe6. It is increasing thermal properties as the Sb is doping in the nano-system. While the electrical conductivity (a) decreased in nano system otherwise the Seebeck coefficient (S) is increased. The different behavior of See-beck co-efficient and electrical conductivity which cause to increase the power factor. Our present study to show that the use of Tl10-xSbxTe6 is best nano-particles for thermos-electric generator.