Unique tandem Heck-lactamization naphthyridinone ring formation between acrylanilides and halogenated pyridines

被引：10

作者：

Cvetovich, Raymond J. ^{[1
]}

Reamer, Robert A. ^{[1
]}

DiMichele, Lisa ^{[1
]}

Chung, John Y. L. ^{[1
]}

Chilenski, Jennifer R. ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Res Labs, Rahway, NJ 07065 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 22期

关键词：

D O I：

10.1021/jo0613479

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Heck coupling of acrylanilides with 4-bromo-2-chloro-3-iodo-pyridine using palladium acetate can produce bis-Heck products or undergo an unusual tandem Heck-lactamization ring formation to generate 5-chloro-1-aryl-1,6-naphthyridin-2(1H)-ones.

引用

页码：8610 / 8613

页数：4

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