Genetic influences in the aetiology of tears of the rotator cuff - Sibling risk of a full-thickness tear

被引：106

作者：

Harvie, P ^{[1
]}

Ostlere, SJ ^{[1
]}

Teh, J ^{[1
]}

McNally, EG ^{[1
]}

Clipsham, K ^{[1
]}

Burston, BJ ^{[1
]}

Pollard, TCB ^{[1
]}

Carr, AJ ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Orthopaed Surg, Nuffield Orthopaed Ctr, Oxford OX3 7LD, England

来源：

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME | 2004年 / 86B卷 / 05期

关键词：

D O I：

10.1302/0301-620X.86B5.14747

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

From a retrospective, cohort study of 205 patients diagnosed with full-thickness tears of the rotator cuff, we determined, using ultrasound, the prevalence of such tears in their 129 siblings. Using 150 spouses as controls, the relative risk of full-thickness tears in siblings versus controls was 2.42 (95% CI 1.77 to 3.31). The relative risk of symptomatic full-thickness tears in siblings versus controls was 4.65 (95% CI 2.42 to 8.63). The significantly increased risk for tears in siblings implies that genetic factors play a major role in the development of full-thickness tears of the rotator cuff.

引用

页码：696 / 700

页数：5

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