Does the age of breast cancer diagnosis in first-degree relatives impact on the risk of breast cancer in BRCA1 and BRCA2 mutation carriers?

被引:4
作者
Semple, John [1 ]
Metcalfe, Kelly A. [1 ,2 ]
Lubinski, Jan [3 ]
Huzarski, Tomasz [3 ]
Gronwald, Jacek [3 ]
Armel, Susan [4 ]
Lynch, Henry T. [5 ]
Karlan, Beth [6 ]
Foulkes, William [7 ]
Singer, Christian F. [8 ,9 ]
Neuhausen, Susan L. [10 ]
Eng, Charis [11 ,12 ,13 ,14 ,15 ]
Iqbal, Javaid [1 ]
Narod, Steven A. [1 ]
机构
[1] Womens Coll Res Inst, Toronto, ON, Canada
[2] Univ Toronto, Lawrence S Bloomberg Fac Nursing, Toronto, ON, Canada
[3] Pomeranian Med Univ, Hereditary Canc Ctr, Szczecin, Poland
[4] Univ Hlth Network, Toronto, ON, Canada
[5] Creighton Univ, Sch Med, Dept Prevent Med & Publ Hlth, Omaha, NE USA
[6] Cedars Sinai Med Ctr, Dept Obstet & Gynecol, Beverly Hills, CA USA
[7] McGill Univ, Dept Oncol & Human Genet, Montreal, PQ, Canada
[8] Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria
[9] Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
[10] City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA
[11] Taussig Canc Inst, Genom Med Inst, Cleveland, OH USA
[12] Taussig Canc Inst, Ctr Personalized Genet Healthcare, Cleveland, OH USA
[13] Cleveland Clin, Stanley Shalom Zielony Inst Nursing Excellence, Cleveland, OH 44106 USA
[14] Case Western Reserve Univ, Sch Med, CASE Comprehens Canc Ctr, Dept Genet & Genome Sci, Cleveland, OH USA
[15] Case Western Reserve Univ, Sch Med, CASE Comprehens Canc Ctr, Germline High Risk Canc Focus Grp, Cleveland, OH USA
关键词
Breast cancer; BRCA1; BRCA2; Age; Diagnosis; FAMILY-HISTORY; OVARIAN-CANCER; WOMEN;
D O I
10.1007/s10549-015-3596-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The purpose of this study is to estimate the age-specific annual risks of breast cancer in a woman with a germline BRCA mutation and an affected first-degree relative according to the age of breast cancer diagnosis in the relative. Women with BRCA mutations with no previous diagnosis of breast cancer and with one first-degree relative with breast cancer were followed for breast cancers for a mean of 5.9 years (minimum 2 years). Age-specific annual breast cancer risks were calculated, according to the age of breast cancer diagnosis in the proband and the first-degree relative. 1114 cancer-free women with a BRCA mutation with a single first-degree relative with breast cancer were eligible for the study. 122 women (11.0 %) were diagnosed with incident breast cancer. The annual risk of breast cancer was 2.0 % for women with BRCA1 mutations and was 1.6 % for women with BRCA2 mutations. The age of breast cancer diagnosis in the first-degree relative did not affect the annual breast cancer risks for BRCA1 mutation carriers. For BRCA2 mutation carriers, the annual breast cancer risk was 4.5 % for women with a first-degree relative diagnosed with breast cancer under the age of 30 years and was 0.7 % for women with a relative diagnosed over the age of 60. Among women with BRCA2 mutations, a family history of early-onset breast cancer is a risk factor for developing breast cancer. Risk assessment for healthy BRCA2 mutation carriers should consider the ages of breast cancers diagnosed in first-degree relatives.
引用
收藏
页码:163 / 169
页数:7
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