Search for schizophrenia susceptibility genes

identification of a gene or genes that contribute to the development of schizophrenia, a complex psychiatric disorder, may be possible through genetic linkage analysis. Although to date no single causative gene has been identified several chromosomal loci have shown positive linkage results and are under investigation as tentative schizophrenia susceptibility loci. Despite such obstacles as locus heterogeneity among sample populations, epistatic inheritance models, and failure to obtain statistical significance in studies, patterns have emerged that focus research efforts on chromosomes 13, 8, 22, and 6 and 10. Initial heterogeneity analyses suggests that identifiable subgroups of the families may not contribute equally to these linkage findings. Findings on several additional chromosomes await further replication. Future progress in the search for schizophrenia susceptibility genes will require collaboration among researchers from both academia and industry. Biol Psychiatry 2000;47:221-230 (C) 2000 Society of Biological Psychiatry.