Clinically Available Pharmacogenomics Tests

被引：54
作者：
Flockhart, D. A. [1 ]
Skaar, T. [1 ]
Berlin, D. S. [2 ]
Klein, T. E. [2 ]
Nguyen, A. T. [1 ]
机构：
[1] Indiana Univ, Sch Med, Dept Med, Div Clin Pharmacol, Indianapolis, IN 46204 USA
[2] Stanford Univ, Dept Genet, Stanford, CA 94305 USA
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2009年 / 86卷 / 01期
关键词：
COLORECTAL-CANCER; GENETIC-VARIANTS; TOXICITY; IRINOTECAN; TAMOXIFEN; WARFARIN; GENOME; ANTICOAGULATION; ASSOCIATION; METABOLISM;
D O I：
10.1038/clpt.2009.39
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The development of robust and clinically valuable pharmacogenomic tests has been anticipated to be one of the first tangible results of the Human Genome Project. Despite both obvious and unanticipated obstacles, a number of tests have now become available in various practice settings. Lessons can be learned from examination of these tests, the evidence that has catalyzed their use, their value to prescribers, and their merit as tools for personalizing therapeutics.
引用
收藏
页码：109 / 113
页数：5
相关论文
共 31 条
  • [1] An association between clozapine-induced agranulocytosis in schizophrenics and HLA-DQB1*0201
    Amar, A
    Segman, RH
    Shtrussberg, S
    Sherman, L
    Safirman, C
    Lerer, B
    Brautbar, C
    [J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 1998, 1 (01) : 41 - 44
  • [2] Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    Birney, Ewan
    Stamatoyannopoulos, John A.
    Dutta, Anindya
    Guigo, Roderic
    Gingeras, Thomas R.
    Margulies, Elliott H.
    Weng, Zhiping
    Snyder, Michael
    Dermitzakis, Emmanouil T.
    Stamatoyannopoulos, John A.
    Thurman, Robert E.
    Kuehn, Michael S.
    Taylor, Christopher M.
    Neph, Shane
    Koch, Christoph M.
    Asthana, Saurabh
    Malhotra, Ankit
    Adzhubei, Ivan
    Greenbaum, Jason A.
    Andrews, Robert M.
    Flicek, Paul
    Boyle, Patrick J.
    Cao, Hua
    Carter, Nigel P.
    Clelland, Gayle K.
    Davis, Sean
    Day, Nathan
    Dhami, Pawandeep
    Dillon, Shane C.
    Dorschner, Michael O.
    Fiegler, Heike
    Giresi, Paul G.
    Goldy, Jeff
    Hawrylycz, Michael
    Haydock, Andrew
    Humbert, Richard
    James, Keith D.
    Johnson, Brett E.
    Johnson, Ericka M.
    Frum, Tristan T.
    Rosenzweig, Elizabeth R.
    Karnani, Neerja
    Lee, Kirsten
    Lefebvre, Gregory C.
    Navas, Patrick A.
    Neri, Fidencio
    Parker, Stephen C. J.
    Sabo, Peter J.
    Sandstrom, Richard
    Shafer, Anthony
    [J]. NATURE, 2007, 447 (7146) : 799 - 816
  • [3] THE GENETIC-BASIS OF THE REDUCED EXPRESSION OF BILIRUBIN UDP-GLUCURONOSYLTRANSFERASE-1 IN GILBERTS-SYNDROME
    BOSMA, PJ
    CHOWDHURY, JR
    BAKKER, C
    GANTLA, S
    DEBOER, A
    OOSTRA, BA
    LINDHOUT, D
    TYTGAT, GNJ
    JANSEN, PLM
    ELFERINK, RPJO
    CHOWDHURY, NR
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (18) : 1171 - 1175
  • [4] CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation:: A prospective randomized controlled study
    Caraco, Y.
    Blotnick, S.
    Muszkat, M.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2008, 83 (03) : 460 - 470
  • [5] A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose
    Cooper, Gregory M.
    Johnson, Julie A.
    Langaee, Taimour Y.
    Feng, Hua
    Stanaway, Ian B.
    Schwarz, Ute I.
    Ritchie, Marylyn D.
    Stein, C. Michael
    Roden, Dan M.
    Smith, Joshua D.
    Veenstra, David L.
    Rettie, Allan E.
    Rieder, Mark J.
    [J]. BLOOD, 2008, 112 (04) : 1022 - 1027
  • [6] Germline pharmacogenetics of tamoxifen response: Have we learned enough?
    Desta, Zeruesenay
    Flockhart, David A.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (33) : 5147 - 5149
  • [7] FAMILIAL DEFICIENCY OF DIHYDROPYRIMIDINE DEHYDROGENASE - BIOCHEMICAL BASIS FOR FAMILIAL PYRIMIDINEMIA AND SEVERE 5-FLUOROURACIL-INDUCED TOXICITY
    DIASIO, RB
    BEAVERS, TL
    CARPENTER, JT
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (01) : 47 - 51
  • [8] Payer perspectives on pharmacogenomics testing and drug development
    Epstein, Robert S.
    Frueh, Felix W.
    Geren, Dawn
    Hummer, Doris
    McKibbin, Scott
    O'Connor, Susan
    Randhawa, Gurvaneet
    Zelman, Benjamin
    [J]. PHARMACOGENOMICS, 2009, 10 (01) : 149 - 151
  • [9] Current use of pharmacogenetic testing: a national survey of thiopurine methyltransferase testing prior to azathioprine prescription
    Fargher, E. A.
    Tricker, K.
    Newman, W.
    Elliott, R.
    Roberts, S. A.
    Shaffer, J. L.
    Bruce, I.
    Payne, K.
    [J]. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2007, 32 (02) : 187 - 195
  • [10] The genome gets personal - Almost
    Feero, W. Gregory
    Guttmacher, Alan E.
    Collins, Francis S.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (11): : 1351 - 1352
1234