Clinically Available Pharmacogenomics Tests

被引：54

作者：

Flockhart, D. A. ^{[1
]}

Skaar, T. ^{[1
]}

Berlin, D. S. ^{[2
]}

Klein, T. E. ^{[2
]}

Nguyen, A. T. ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Med, Div Clin Pharmacol, Indianapolis, IN 46204 USA

[2] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2009年 / 86卷 / 01期

关键词：

COLORECTAL-CANCER; GENETIC-VARIANTS; TOXICITY; IRINOTECAN; TAMOXIFEN; WARFARIN; GENOME; ANTICOAGULATION; ASSOCIATION; METABOLISM;

D O I：

10.1038/clpt.2009.39

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The development of robust and clinically valuable pharmacogenomic tests has been anticipated to be one of the first tangible results of the Human Genome Project. Despite both obvious and unanticipated obstacles, a number of tests have now become available in various practice settings. Lessons can be learned from examination of these tests, the evidence that has catalyzed their use, their value to prescribers, and their merit as tools for personalizing therapeutics.

引用

页码：109 / 113

页数：5

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