Strategies for mining fungal natural products

被引：152

作者：

Wiemann, Philipp ^{[1
]}

Keller, Nancy P. ^{[1
,2
]}

机构：

[1] Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA

来源：

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | 2014年 / 41卷 / 02期

关键词：

Secondary metabolism; Gene clusters; Polyketide; Non-ribosomal peptide; LaeA; BIOSYNTHETIC GENE-CLUSTER; COMPLETE GENOME SEQUENCE; SECONDARY METABOLITE BIOSYNTHESIS; DNA-BINDING PROTEIN; VELVET-LIKE COMPLEX; POLYKETIDE SYNTHASE; ASPERGILLUS-NIDULANS; HETEROLOGOUS EXPRESSION; PENICILLIUM-CHRYSOGENUM; FUSARIUM-FUJIKUROI;

D O I：

10.1007/s10295-013-1366-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Fungi are well known for their ability to produce a multitude of natural products. On the one hand their potential to provide beneficial antibiotics and immunosuppressants has been maximized by the pharmaceutical industry to service the market with cost-efficient drugs. On the other hand identification of trace amounts of known mycotoxins in food and feed samples is of major importance to ensure consumer health and safety. Although several fungal natural products, their biosynthesis and regulation are known today, recent genome sequences of hundreds of fungal species illustrate that the secondary metabolite potential of fungi has been substantially underestimated. Since expression of genes and subsequent production of the encoded metabolites are frequently cryptic or silent under standard laboratory conditions, strategies for activating these hidden new compounds are essential. This review will cover the latest advances in fungal genome mining undertaken to unlock novel products.

引用

页码：301 / 313

页数：13

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