Idiopathic membranous nephropathy associated to cyclosporine toxicity.: Prognosis and other inmunosupresive treatments

A 32 year-old male patient was admitted at our department presenting microhematuria and full nephrotic syndrome in april 1995. A percutaneus kidney biopsy proved a stage I-II membranous nephropathy and an eight-week course with oral prednisone was initiated without response. Then, oral ciclosporine A (3.5 mg/kg/day) was given and after 5 weeks of treatment, remmision of the nephrotic syndrome was observed but creatinine raised to 1.6 mg/dl, normalizing after reducing the dose of ciclosporine A. We discuss the settings, prognostic and therapeutic alternatives for idiopathic membranous nephropathy.