A New KIT Mutation (N505I) in Acral Melanoma Confers Constitutive Signaling, Favors Tumorigenic Properties, and Is Sensitive to Imatinib

被引：4

作者：

Allegra, Maryline ^{[1
,2
]}

Giacchero, Damien ^{[2
]}

Segalen, Coralie ^{[1
]}

Dumaz, Nicolas ^{[3
]}

Butori, Catherine ^{[5
,6
]}

Hofman, Veronique ^{[4
,5
,6
]}

Hofman, Paul ^{[4
,5
,6
]}

Lacour, Jean-Philippe ^{[2
,4
]}

Bertolotto, Corine ^{[1
,4
]}

Bahadoran, Philippe ^{[1
,2
,4
,7
]}

Ballotti, Robert ^{[1
,2
,4
]}

机构：

[1] Fac Med Nice, INSERM, Ctr Mediterraneen Med Mol C3M,Equipe 1,U1065, Equipe Labellisee Ligue Canc Biol & Pathol Melano, F-06034 Nice, France

[2] CHU Nice, Dept Dermatol, F-06202 Nice, France

[3] Univ Paris Diderot, Sorbonne Paris Cite, INSERM, U976, Paris, France

[4] Univ Nice Sophia Antipolis, UFR Med, F-06189 Nice, France

[5] Fac Med Nice, INSERM, IRCAN Equipe 3, U1081, F-06034 Nice, France

[6] Fac Med Nice, INSERM, Hosp Integrated Tumor Biobank, U1081, F-06034 Nice, France

[7] CHU Nice, Clin Res Ctr, F-06202 Nice, France

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2014年 / 134卷 / 05期

关键词：

MUCOSAL MELANOMAS; DISTINCT SUBTYPES; MELANOCYTES; ACTIVATION; SORAFENIB; TUMORS;

D O I：

10.1038/jid.2013.525

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

引用

页码：1473 / 1476

页数：4

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