The Neuroprotective Effects of Thymoquinone: A Review

被引：106

作者：

Farkhondeh, Tahereh ^{[1
]}

Samarghandia, Saeed ^{[2
]}

Shahri, Ali Mohammad Pourbagher ^{[3
]}

Samini, Fariborz ^{[4
]}

机构：

[1] Birjand Univ Med Sci, Cardiovasc Dis Res Ctr, Birjand, Iran

[2] Neyshabur Univ Med Sci, Dept Basic Med Sci, Neyshabur, Iran

[3] Birjand Univ Med Sci, Fac Med, Birjand, Iran

[4] Mashhad Univ Med Sci, Dept Neurosurg, Fac Med, Mahhad, Iran

来源：

DOSE-RESPONSE | 2018年 / 16卷 / 02期

关键词：

neurodegenerative diseases; thymoquinone; antioxidant; anti-inflammation; apoptosis; SEED NIGELLA-SATIVA; CHRONIC TOLUENE EXPOSURE; NRF2-ARE SIGNAL PATHWAY; OXIDATIVE STRESS; ALPHA-SYNUCLEIN; ALLOSTERIC MODULATOR; ISCHEMIA-REPERFUSION; ALZHEIMERS-DISEASE; LIPID-PEROXIDATION; VOLATILE OIL;

D O I：

10.1177/1559325818761455

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Thymoquinone (TQ), one of the main components active of Nigella sativa, exhibited very useful biomedical effects such as anti-inflammatory, antioxidant, antimicrobial, antiparasitic, anticancer, hypoglycemic, antihypertensive, and antiasthmatic effects. There are several studies about pharmacological activities of TQ but its neuroprotection effects are not fully described. The literature search has indicated many studies pertaining to the effects of TQ in neurological problems such as epilepsy, parkinsonism, anxiety, and improvement of learning and memory, and so on. In addition, TQ protected brain cells from various injuries due to its antioxidant, anti-inflammatory, and apoptotic effects in cell line and experimental animal models. The present study has been designed to review the scientific literature about the pharmacological activities of TQ to the neurological diseases. This study purposed that although experimental studies indicated the beneficial effects of TQ against nervous system problems, better designed clinical trials in humans are needed to confirm these effects.

引用

页数：11

共 108 条

[1] DYNAMICS OF CEREBRAL EDEMA - ROLE OF AN INTACT VASCULAR BED IN THE PRODUCTION AND PROPAGATION OF VASOGENIC BRAIN EDEMA
AARABI, B
LONG, DM
[J]. JOURNAL OF NEUROSURGERY, 1979, 51 (06) : 779 - 784
[2] Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice
Abdel-Fattah, AFM
Matsumoto, K
Watanabe, H
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 400 (01) : 89 - 97
[3] The Effect of Route of Administration in Thymoquinone Toxicity in Male and Female Rats
AbuKhader, M. M.
[J]. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 74 (03) : 195 - 200
[4] Ahmad Aftab, 2013, Asian Pacific Journal of Tropical Biomedicine, V3, P337, DOI 10.1016/S2221-1691(13)60075-1
[5] The effect of thymoquinone on intractable pediatric seizures (pilot study)
Akhondian, Javad
Kianifar, Hamidreza
Raoofziaee, Mohammad
Moayedpour, Amir
Toosi, Mehran Beiraghi
Khajedaluee, Mohammad
[J]. EPILEPSY RESEARCH, 2011, 93 (01) : 39 - 43
[6] Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus
Al-Majed, Abdulhakeem A.
Al-Omar, Fadhel A.
Nagi, Mahmoud N.
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 543 (1-3) : 40 - 47
[7] Al-Shabanah OA, 1998, J EXP CLIN CANC RES, V17, P193
[8] Thymoquinone protects cultured hippocampal and human induced pluripotent stem cells-derived neurons against α-synuclein-induced synapse damage
Alhebshi, A. H.
Odawara, A.
Gotoh, M.
Suzuki, I.
[J]. NEUROSCIENCE LETTERS, 2014, 570 : 126 - 131
[9] Thymoquinone protects cultured rat primary neurons against amyloid β-induced neurotoxicity
Alhebshi, A. H.
Gotoh, M.
Suzuki, I.
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 433 (04) : 362 - 367
[10] The effect of thymoquinone treatment on the combined renal and pulmonary toxicity of cisplatin and diesel exhaust particles
Ali, Badreldin H.
Al Za'abi, Mohammed
Shalaby, Asem
Manoj, Priyadarsini
Waly, Mostafa I.
Yasin, Javed
Fahim, Mohamed
Nemmar, Abderrahim
[J]. EXPERIMENTAL BIOLOGY AND MEDICINE, 2015, 240 (12) : 1698 - 1707

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