MicroRNA-301a promotes pancreatic cancer invasion and metastasis through the JAK/STAT3 signaling pathway by targeting SOCS5

被引：56

作者：

Hu, Hui ^{[1
]}

Zhang, Qin ^{[1
,2
]}

Chen, Weiqun ^{[1
,3
,4
]}

Wu, Tangwei ^{[1
]}

Liu, Shuiyi ^{[1
,3
]}

Li, Xiaoyi ^{[1
]}

Luo, Bo ^{[5
]}

Zhang, Tianzhu ^{[1
,2
]}

Yan, Ge ^{[1
,2
]}

Lu, Hongda ^{[3
,6
]}

Lu, Zhongxin ^{[1
,2
,3
,4
]}

机构：

[1] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Med Lab, Wuhan 430014, Peoples R China

[2] Hubei Univ Chinese Med, Sch Lab Med, Wuhan 430065, Peoples R China

[3] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Canc Res Inst Wuhan, Wuhan 430014, Peoples R China

[4] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Key Lab Mol Diag Hubei Prov, Wuhan 430014, Peoples R China

[5] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Pathol, Wuhan 430014, Peoples R China

[6] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Oncol, Wuhan 430014, Peoples R China

来源：

CARCINOGENESIS | 2020年 / 41卷 / 04期

关键词：

CELL-PROLIFERATION; PROGRESSION; EXPRESSION; PROTEINS; IMMUNITY;

D O I：

10.1093/carcin/bgz121

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer is one of the most lethal digestive malignant tumors. We had previously found that microRNA-301a (miR-301a) is a oncogenic microRNA whose recognized conduce to nuclear factor-kappa B (NF-kappa B) activation in pancreatic cancer, yet the underlying mechanisms of miR-301a in promoting pancreatic cancer invasion and migration is obscure. In this work we found that high expression of miR-301a in human pancreatic cancer patients is related to poor survival. Overexpression of miR-301a enhances pancreatic cancer cell invasion, angiogenesis and migration, whereas inhibition of miR-301a suppresses pancreatic cancer cell invasion and reduces orthotopic pancreatic tumor growth and metastasis. Furthermore, suppressor of cytokine signaling 5 (SOCS5) is identified as a target gene of miR-301a. We found that miR-301a suppressed the expression of SOCS5 leads to janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) activation and is related to poor overall survival of pancreatic cancer patients. Taken together, our data show for the first time that the feedback loop between miR-301a and JAK/STAT3 pathway may play a significant role in pancreatic cancer invasion and metastasis. Targeting the loop may prove beneficial to prevent metastasis and provide a more effective therapeutic strategy for pancreatic cancer.

引用

页码：502 / 514

页数：13

共 48 条

[1]

Acunzo Mario, 2015, Adv Biol Regul, V57, P1, DOI 10.1016/j.jbior.2014.09.013

[2] miR-331-3p functions as an oncogene by targeting ST7L in pancreatic cancer [J].