Neuromyelitis optica in patients with myasthenia gravis who underwent thymectomy

被引：61
作者：
Kister, I
Gulati, S
Boz, C
Bergamaschi, R
Piccolo, G
Oger, J
Swerdlow, ML
机构：
[1] Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USA
[2] Long Isl Jewish Med Ctr, New Hyde Pk, NY 11042 USA
[3] Univ British Columbia, Multiple Sclerosis Clin, Vancouver, BC V5Z 1M9, Canada
[4] Neurol Inst C Mondino, Multiple Sclerosis Ctr, Pavia, Italy
来源：
ARCHIVES OF NEUROLOGY | 2006年 / 63卷 / 06期
关键词：
D O I：
10.1001/archneur.63.6.851
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Myasthenia gravis (MG) and neuromyelitis optica (NMO, also known as Devic disease) are rare autoimmune disorders, with upper-limit prevalence estimates in the general population of 15 per 100 000 and 5 per 100 000, respectively. To our knowledge, an association between these diseases has not been previously reported. Objectives: To describe 4 patients with MG who developed NMO after thymectomy and to analyze possible causes of apparent increased prevalence of NMO among patients with MG. Design: Case series. Patients: Four patients with MG who underwent thymectomy. Interventions: None. Results: The prevalence of MG within the published cohort of patients with NMO is more than 150 times higher than that in the general population. Conclusion: Dysregulation of B-cell autoimmunity in myasthenia, possibly exacerbated by loss of control over autoreactive cells as a result of thymectomy, may predispose patients to the development of NMO.
引用
收藏
页码：851 / 856
页数：6
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