Modulation of cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADH and cytochrome b5

被引:1
作者
Indra, Radek [1 ]
Moserova, Michaela [1 ]
Volker, Arlt M. [2 ]
Stiborova, Marie [1 ]
机构
[1] Charles Univ Prague, Dept Biochem, Fac Sci, Prague 2, Czech Republic
[2] Kings Coll London, Analyt & Environm Sci Div, MRC PHE Ctr Environm & Hlth, London WC2R 2LS, England
关键词
D O I
10.1016/j.toxlet.2014.06.525
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
P-3.16
引用
收藏
页码:S150 / S150
页数:1
相关论文
共 50 条
[31]   Exposure to endocrine disruptors 17alpha-ethinylestradiol and estradiol influences cytochrome P450 1A1-mediated genotoxicity of benzo[a]pyrene and expression of this enzyme in rats [J].
Stiborova, Marie ;
Dracinska, Helena ;
Borek-Dohalska, Lucie ;
Klusonova, Zuzana ;
Holecova, Jana ;
Martinkova, Marketa ;
Schmeiser, Heinz H. ;
Arlt, Volker M. .
TOXICOLOGY, 2018, 400 :48-56
[32]   Comparison of cytochrome b5 interactions with some human cytochrome P450 isoforms [J].
Zhao, Chunsheng ;
Roberts, Arthur G. ;
Gao, Qiuxia ;
Atkins, William M. ;
Nelson, Sidney D. .
DRUG METABOLISM REVIEWS, 2011, 43 :31-31
[33]   The interaction of microsomal cytochrome P450 2B4 with its redox partners, cytochrome P450 reductase and cytochrome b5 [J].
Im, Sang-Choul ;
Waskell, Lucy .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2011, 507 (01) :144-153
[34]   Chlorzoxazone Metabolism by Porcine Cytochrome P450 Enzymes and the Effect of Cytochrome b5 [J].
Wiercinska, P. ;
Squires, E. J. .
DRUG METABOLISM AND DISPOSITION, 2010, 38 (05) :857-862
[35]   Cytochrome b5 Binds Tightly to Several Human Cytochrome P450 Enzymes [J].
Kim, Donghak ;
Kim, Vitchan ;
Tateishi, Yasuhiro ;
Guengerich, F. Peter .
DRUG METABOLISM AND DISPOSITION, 2021, 49 (10) :902-909
[36]   NADPH- and NADH-dependent formation of DNA adducts by benzo[a] pyrene catalyzed with cytochrome P450 1A1 [J].
Moserova, M. ;
Indra, R. ;
Milichovsky, J. ;
Frei, E. ;
Schmeiser, H. H. ;
Arlt, V. M. ;
Stiborova, M. .
TOXICOLOGY LETTERS, 2015, 238 (02) :S239-S239
[37]   Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine [J].
Reed, Lindsay ;
Indra, Radek ;
Mrizova, Iveta ;
Moserova, Michaela ;
Schmeiser, Heinz H. ;
Wolf, C. Roland ;
Henderson, Colin J. ;
Stiborova, Marie ;
Phillips, David H. ;
Arlt, Volker M. .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 366 :64-74
[38]   Defining the in Vivo Role for Cytochrome b5 in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b5 [J].
Finn, Robert D. ;
McLaughlin, Lesley A. ;
Ronseaux, Sebastien ;
Rosewell, Ian ;
Houston, J. Brian ;
Henderson, Colin J. ;
Wolf, C. Roland .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (46) :31385-31393
[39]   Evidence That Cytochrome b5 and Cytochrome b5 Reductase Can Act as Sole Electron Donors to the Hepatic Cytochrome P450 Systems [J].
Henderson, Colin J. ;
McLaughlin, Lesley A. ;
Wolf, C. Roland .
MOLECULAR PHARMACOLOGY, 2013, 83 (06) :1209-1217
[40]   Identification of the binding site on cytochrome P4502B4 for cytochrome b5 and cytochrome P450 reductase* [J].
Bridges, A ;
Gruenke, L ;
Changi, YT ;
Vakser, IA ;
Loewi, G ;
Waskell, L .
FASEB JOURNAL, 2000, 14 (08) :A1307-A1307