Folic Acid, Methylation and Neural Tube Closure in Humans

被引：94
作者：
Blom, Henk J. [1 ]
机构：
[1] Free Univ Med Ctr Amsterdam, Dept Clin Chem, Metab Unit, Amsterdam, Netherlands
来源：
BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY | 2009年 / 85卷 / 04期
关键词：
neural tube; CNS; PNS; human embryos; embryogenesis; METHIONINE SYNTHASE REDUCTASE; REDUCED FOLATE CARRIER; CYSTATHIONINE BETA-SYNTHASE; DEHYDROGENASE-METHENYLTETRAHYDROFOLATE-CYCLOHYDROLASE; HOMOCYSTEINE METHYLTRANSFERASE BHMT; GLUTAMATE CARBOXYPEPTIDASE-II; PERICONCEPTIONAL VITAMIN USE; GENE-GENE INTERACTION; RISK-FACTOR; METHYLENETETRAHYDROFOLATE REDUCTASE;
D O I：
10.1002/bdra.20581
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
This review provides a brief description of folate use and folic acid metabolism in relation to neural tube defect (NTD) risk. First, a meta-analysis of reduction in NTD recurrence and occurrence risk with periconceptional folic acid supplementation is presented. Second, an overview of the complex folate metabolism is given. Third, SNPs for genes involved in folate and homocysteine metabolism that have been studied in relation to NTD risk are discussed. Fourth, the questions whether folate receptor autoantibodies or hampered methylation are mechanisms underlying NTDs are briefly discussed. Birth Defects Research (Part A) 85:295302, 2009. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码：295 / 302
页数：8
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