Genetic Circuitry Modulating Notch Signals Through Endosomal Trafficking

被引：1

作者：

Hori, Kazuya ^{[1
]}

Sen, Anindya ^{[1
]}

Artavanis-Tsakonas, Spyros ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

ENDOSOME SIGNALING, PT A | 2014年 / 534卷

关键词：

DROSOPHILA-MELANOGASTER; ESCRT-II; ACTIVATION; COMPLEX; ENDOCYTOSIS; SUPPRESSOR; PATHWAY; ARRESTIN; LIGAND; VPS25;

D O I：

10.1016/B978-0-12-397926-1.00016-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic modifier screens offer a powerful, indeed a uniquely powerful tool for the analysis and identification of elements capable of modulating specific cellular functions in development. Here, we describe the methodology that allowed us to explore the genetic circuitry that affects a Notch mutant phenotype caused by the abnormal endosomal trafficking of the Notch receptor. Endosomal trafficking events are increasingly appreciated to play a major role in controlling Notch signaling in development.

引用

页码：283 / 299

页数：17

共 35 条

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JOURNAL OF CELL SCIENCE, 2014, 127 (11) : 2407 - 2419
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ENDOSOME SIGNALING, PT A, 2014, 534 : 301 - 321
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2025, 1871 (05):
[8] Influenza A virus enhances its propagation through the modulation of Annexin-A1 dependent endosomal trafficking and apoptosis
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[10] Trafficking of galectin-3 through endosomal organelles of polarized and non-polarized cells
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EUROPEAN JOURNAL OF CELL BIOLOGY, 2010, 89 (11) : 788 - 798

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