Identification of oxidative stress-regulated genes in rat aortic smooth muscle cells by suppression subtractive hybridization

被引：17

作者：

Sakamoto, K ^{[1
]}

Yamasaki, Y ^{[1
]}

Kaneto, H ^{[1
]}

Fujitani, Y ^{[1
]}

Matsuoka, T ^{[1
]}

Yoshioka, R ^{[1
]}

Tagawa, T ^{[1
]}

Matsuhisa, M ^{[1
]}

Kajimoto, Y ^{[1
]}

Hori, M ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, Osaka 5650871, Japan

来源：

FEBS LETTERS | 1999年 / 461卷 / 1-2期

关键词：

atherosclerosis; oxidative stress; smooth muscle cell;

D O I：

10.1016/S0014-5793(99)01419-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A suppression subtractive hybridization technique was used to identify reactive oxygen species (ROS)-regulated genes in rat vascular smooth muscle cells. Three genes out of 89 clones, identified as fibronectin, p105 coactivator and ECA39, showed increased expression after treatment with H2O2. The mRNA expressions of these three genes were induced in a time- and dose-dependent manner, independent of protein kinase C activation. Immunohistochemical staining showed that the p105 coactivator expression was markedly induced in the neointima of balloon-injured rat carotid arteries, These results suggest that ROS may play an important role in the development of atherosclerosis by regulating the gene expressions we identified in this study. (C) 1999 Federation of European Biochemical Societies.

引用

页码：47 / 51

页数：5

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