Inhaled nitric oxide prevents systemic and pulmonary vasoconstriction due to hemoglobin-based oxygen carrier infusion: A case report

被引：12

作者：

Marrazzo, Francesco ^{[1
]}

Larson, Grant ^{[1
]}

Lama, Tenzing T. Sherpa ^{[1
]}

Droghi, Maddalena Teggia ^{[1
]}

Joyce, Maurice ^{[1
]}

Ichinose, Fumito ^{[1
]}

Watkins, Michael T. ^{[2
]}

Stowell, Christopher ^{[3
]}

Crowley, Jerome ^{[1
]}

Berra, Lorenzo ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, White 434B,55 Fruit St, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Vasc Surg Div, Dept Surg, 55 Fruit St, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Dept Pathol, Blood Transfus Serv, 55 Fruit St, Boston, MA 02114 USA

来源：

JOURNAL OF CRITICAL CARE | 2019年 / 51卷

关键词：

Nitric oxide; Hemoglobin based oxygen carrier (HBOC); Vasoconstriction; BLOOD; HBOC-201; SUBSTITUTES;

D O I：

10.1016/j.jcrc.2018.04.008

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Hemoglobin-based oxygen carriers (HBOCs) are used in extreme circumstances to increase hemoglobin concentration and improve oxygen delivery when allogenic red blood cell transfusions are contraindicated or not immediately available. However, HBOC-induced severe pulmonary and systemic vasoconstriction due to peripheral nitric oxide (NO) scavenging has stalled its implementation in clinical practice. We present a case of an 87 year-old patient with acute life-threatening anemia who received HBOC while breathing NO gas. This case shows that inhaled NO allows for the safe use of HBOC infusion by preventing HBOC-induced pulmonary and systemic vasoconstriction. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：213 / 216

页数：4

共 47 条

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