Cancer biology in diabetes

被引：25

作者：

Sen, Shi ^{[1
,2
]}

He, Yanzheng ^{[2
]}

Koya, Daisuke ^{[1
]}

Kanasaki, Keizo ^{[1
]}

机构：

[1] Kanazawa Med Univ, Div Diabet & Endocrinol, Kanazawa, Ishikawa, Japan

[2] Luzhou Med Coll, Dept Vasc & Thyroid Surg, Affiliated Hosp, Luzhou, Peoples R China

来源：

JOURNAL OF DIABETES INVESTIGATION | 2014年 / 5卷 / 03期

基金：

日本学术振兴会;

关键词：

Antidiabetic drugs; Cancer; Diabetes; POPULATION-BASED COHORT; ACTIVATED-RECEPTOR-GAMMA; ALL-CAUSE MORTALITY; BREAST-CANCER; PANCREATIC-CANCER; INSULIN GLARGINE; THYROID-CANCER; PROSTATE-CANCER; COLON-CANCER; HEPATOCELLULAR-CARCINOMA;

D O I：

10.1111/jdi.12208

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes is a serious metabolic disease that causes multiple organ dysfunctions. Recent evidence suggests that diabetes could contribute to the initiation and progression of certain cancers in addition to the classic diabetic complications. Furthermore, some of the drugs used clinically to treat patients with diabetes might affect cancer initiation, progression and mortality. The recent discovery of the possible anticancer effects of metformin, a classic antidiabetic drug, has led physicians and scientists to reconsider the interaction between diabetes and cancer. In the present review, we analyze recent reports in this field, and explore possible mechanistic links between diabetes and cancer biology.

引用

页码：251 / 264

页数：14

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