Urine glycyl-L-proline increase and skin trophicity

被引:9
作者
Le, J [1 ]
Perier, C [1 ]
Peyroche, S [1 ]
Rascle, F [1 ]
Blanchon, MA [1 ]
Gonthier, R [1 ]
Frey, J [1 ]
Chamson, A [1 ]
机构
[1] Fac Med, Biochim Lab, F-42023 St Etienne, France
关键词
amino acids; glycyl-L-proline; urine; trophicity; collagen;
D O I
10.1007/BF01366930
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glycyl-L-proline (gly-pro) is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins. We postulated a relationship between defective gly-pro hydrolysis, increased collagen degradation and skin destruction. This relationship was tested using HPLC to measure the gig-pro in urine. 24 hour urine samples were collected from 27 old people (86 +/- 6 years old), of whom 15 were suffering from skin pressure sores of the sacrum or calcaneus. The urine from patients with pressure sores contained significantly more gly-pro than the urine from the control. A cut-off at 7 mu mol/mmol creatinine gave the test a positive predictive value of 70%. Collagen breakdown was also increased as indicated by the increase of hydroxyproline (hyp) in the urine. But this breakdown seemed to stop at the gly-pro step.
引用
收藏
页码:315 / 322
页数:8
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