Urine glycyl-L-proline increase and skin trophicity

被引：9

作者：

Le, J ^{[1
]}

Perier, C ^{[1
]}

Peyroche, S ^{[1
]}

Rascle, F ^{[1
]}

Blanchon, MA ^{[1
]}

Gonthier, R ^{[1
]}

Frey, J ^{[1
]}

Chamson, A ^{[1
]}

机构：

[1] Fac Med, Biochim Lab, F-42023 St Etienne, France

来源：

AMINO ACIDS | 1999年 / 17卷 / 03期

关键词：

amino acids; glycyl-L-proline; urine; trophicity; collagen;

D O I：

10.1007/BF01366930

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycyl-L-proline (gly-pro) is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins. We postulated a relationship between defective gly-pro hydrolysis, increased collagen degradation and skin destruction. This relationship was tested using HPLC to measure the gig-pro in urine. 24 hour urine samples were collected from 27 old people (86 +/- 6 years old), of whom 15 were suffering from skin pressure sores of the sacrum or calcaneus. The urine from patients with pressure sores contained significantly more gly-pro than the urine from the control. A cut-off at 7 mu mol/mmol creatinine gave the test a positive predictive value of 70%. Collagen breakdown was also increased as indicated by the increase of hydroxyproline (hyp) in the urine. But this breakdown seemed to stop at the gly-pro step.

引用

页码：315 / 322

页数：8

共 11 条

[1] NUTRITIONAL ASPECTS OF COLLAGEN-METABOLISM [J].