DNA helicases in inherited human disorders

被引：114
|
作者：
Ellis, NA
机构：
[1] Laboratory of Human Genetics, New York Blood Center, New York, NY 10021
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 03期
关键词：
D O I：
10.1016/S0959-437X(97)80149-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Six known or predicted helicases that are mutated in human syndromes are now recognized. These syndromes include xeroderma pigmentosum, Cockayne's syndrome, trichothiodystrophy, Bloom's syndrome, Werner's syndrome, and alpha-thalassemia mental retardation on the X chromosome. The clinical abnormalities in these syndromes cover a broad spectrum, pointing to different cellular processes of DNA manipulation that are defective in these syndromes.
引用
收藏
页码：354 / 363
页数：10
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