Telomeres and telomerase in normal and leukemic hematopoietic cells

被引：8

作者：

Engelhardt, M ^{[1
]}

Wäsch, R ^{[1
]}

Guo, YL ^{[1
]}

机构：

[1] Univ Freiburg, Med Ctr, Dept Hematol Oncol, D-79106 Freiburg, Germany

来源：

LEUKEMIA RESEARCH | 2004年 / 28卷 / 10期

关键词：

telomere; telomerase; genomic instability; MDS; AML;

D O I：

10.1016/j.leukres.2004.01.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Telomere length and telomerase have an important role in normal and malignant hematopoiesis. Telomere erosion can lead to chromosome end fusion and thereby contribute to genomic instability during tumorigenesis. Thus, like complex chromosomal aberrations, telomere length ilia), be a prognostic factor in hematopoietic malignancies. A paper by Sieglova et al. in this issue of Leukemia Research reports on the prognostic impact of telomere shortening in bone marrow (BM) and peripheral blood (PB) specimens of myelodysplastic syndrome (MDS) and MDS converted-AML patients (pts). Their results underline the importance to study telomere biology together with cytogenetics, genomic and proteomic profiling as prognostic factors, in order to improve risk-adapted therapy of NIDS and AML pts. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1001 / 1004

页数：4

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