Synthesis and biological activities of some thiazolidin-4-ones

被引：0
作者：
Ozadah, Keriman
Ozkanh, Fugen [1 ]
Erol, Dilek
Dogan, Ali Evrim
Erol, Kevser
机构：
[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey
[2] Yeditepe Univ, Fac Pharm, Istanbul, Turkey
[3] Osman Gazi Univ, Fac Med, Dept Pharmacol, Eskisehir, Turkey
来源：
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 2006年 / 56卷 / 10期
关键词：
antihistaminic agents; thiazolidin-4-ones; anticholinergic activity; antihistaminic activity; synthesis;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this study, fifteen 2,3-disubstituted-4-thiazolidinone derivatives were synthesized by the reaction of Schiff bases and a-mercaptoacetic acid. The structures of the compounds were elucidated by IR, H-1-NMR, C-13-NMR, mass spectral data and elementary analysis. The antihist-aminic and anticholinergic activities of the compounds were determined by tests performed on isolated guinea pig trachea in comparison with aminophylline (CAS 317-34-0). Compound 15 (3-[3-(2-methyl-piperidine-1-yl)propyl]-2-(4-methyl- phenyl)thiazolidin-4-one hydrochloride) showed the highest inhibition (53%).
引用
收藏
页码：678 / 681
页数：4
相关论文
共 50 条
  • [21] Synthesis and biological activities of some new formazans, part-I
    Bharadwaj, SD
    ASIAN JOURNAL OF CHEMISTRY, 2002, 14 (02) : 767 - 770
  • [22] Synthesis and antimicrobial activities of N-chloroacetyl-2,6-diarylpiperidin-4-ones
    Aridoss, G.
    Balasubramanian, S.
    Parthiban, P.
    Ramachandran, R.
    Kabilan, S.
    MEDICINAL CHEMISTRY RESEARCH, 2007, 16 (04) : 188 - 204
  • [23] Synthesis and fungicidal activities of 2-alkylthio-5-phenylmethylene-4H-imidazol-4-ones
    Sun, Y
    Ding, MW
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2003, 178 (10) : 2137 - 2145
  • [24] Synthesis and antimicrobial activities of N-chloroacetyl-2,6-diarylpiperidin-4-ones
    G. Aridoss
    S. Balasubramanian
    P. Parthiban
    R. Ramachandran
    S. Kabilan
    Medicinal Chemistry Research, 2007, 16 : 188 - 204
  • [25] Synthesis, characterization, biological, and molecular docking assessment of bioactive 1,3-thiazolidin-4-ones fused with 1-(pyrimidin-2-yl)-1H-imidazol-4-yl) moieties
    Arshad, Mohammad
    Khan, Mohd Shoeb
    Nami, Shahab A. A.
    Ahmad, Syed Ishraque
    Kashif, Mohd
    Anjum, Ansar
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2021, 18 (07) : 1713 - 1727
  • [26] Synthesis, characterization, biological, and molecular docking assessment of bioactive 1,3-thiazolidin-4-ones fused with 1-(pyrimidin-2-yl)-1H-imidazol-4-yl) moieties
    Mohammad Arshad
    Mohd Shoeb Khan
    Shahab A. A. Nami
    Syed Ishraque Ahmad
    Mohd Kashif
    Ansar Anjum
    Journal of the Iranian Chemical Society, 2021, 18 : 1713 - 1727
  • [27] STUDIES ON THE SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF SOME NEW HETEROCYCLIC MOITIES CONTAINING 1, 2, 4-TRIAZOLES
    Tajkhan, Pathan Vahid
    Ahmed, Ansari Yaasir A. R.
    Rumana, Umme U. G.
    Afroza, Patel
    Ahmad, Anwar
    Razi, Ansari Mohd
    Amreen, Siddiqui Nameera
    INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH, 2020, 10 : 4 - 9
  • [28] SYNTHESIS, BIOLOGICAL ACTIVITIES, AND TAUTOMERISM OF 4-QUINOLONES AND RELATED COMPOUNDS
    Kurasawa, Yoshihisa
    Sasaki, Kenji
    HETEROCYCLES, 2015, 91 (01) : 1 - 39
  • [29] Nonclassical antifolates, part 3: Synthesis, biological evaluation and molecular modeling study of some new 2-heteroarylthio-quinazolin-4-ones
    Al-Omary, Fatmah A. M.
    Hassan, Ghada S.
    El-Messery, Shahenda M.
    Nagi, Mahmoud N.
    Habib, El-Sayed E.
    El-Subbagh, Hussein I.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 63 : 33 - 45
  • [30] Synthesis of some new 4-iminothiazolidine-2-ones as possible antioxidants agents
    Chaban, Taras
    Ogurtsov, Volodymyr
    Chaban, Ihor
    Myrko, Iryna
    Harkov, Stefan
    Lelyukh, Maryan
    PHARMACIA, 2019, 66 (01) : 27 - 32
12345