Cardiovascular Manifestations and Mechanisms in Patients with COVID-19

被引:49
|
作者
Dou, Qingyu [1 ,2 ]
Wei, Xin [3 ]
Zhou, Kehua [2 ,4 ]
Yang, Shujuan [2 ,5 ,6 ]
Jia, Peng [2 ,7 ]
机构
[1] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Geriatr Med Ctr, Chengdu, Peoples R China
[2] Int Inst Spatial Lifecourse Epidemiol ISLE, Hong Kong, Peoples R China
[3] Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Peoples R China
[4] ThedaCare Reg Med Ctr Appleton, Dept Hosp Med, Appleton, WI USA
[5] Sichuan Univ, West China Sch Publ Hlth, Chengdu, Peoples R China
[6] Sichuan Univ, West China Hosp 4, Chengdu, Peoples R China
[7] Hong Kong Polytech Univ, Dept Land Surveying & Geoinformat, Hong Kong, Peoples R China
来源
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2020年 / 31卷 / 12期
基金
国家重点研发计划;
关键词
CLINICAL CHARACTERISTICS; MYOCARDIAL-INFARCTION; CORONAVIRUS; INFECTIONS; PNEUMONIA; OUTCOMES; SARS; WUHAN; ACE2;
D O I
10.1016/j.tem.2020.10.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Coronavirus disease 2019 (COVID-19) patients with pre-existing cardiovascular disease (CVD) or with cardiovascular complications have a higher risk of mortality. The main cardiovascular complications of COVID-19 include acute cardiac injury, acute myocardial infarction (AMI), myocarditis, arrhythmia, heart failure, shock, and venous thromboembolism (VTE)/pulmonary embolism (PE). COVID-19 can cause cardiovascular complications or deterioration of coexisting CVD through direct or indirect mechanisms, including viral toxicity, dysregulation of the renin-angiotensin-aldosterone system (RAAS), endothelial cell damage and thromboinflammation, cytokine storm, and oxygen supply-demand mismatch. We systematically review cardiovascular manifestations, histopathology, and mechanisms of COVID-19, to help to formulate future research goals and facilitate the development of therapeutic management strategies.
引用
收藏
页码:893 / 904
页数:12
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