Cardiovascular Manifestations and Mechanisms in Patients with COVID-19

被引：56

作者：

Dou, Qingyu ^{[1
,2
]}

Wei, Xin ^{[3
]}

Zhou, Kehua ^{[2
,4
]}

Yang, Shujuan ^{[2
,5
,6
]}

Jia, Peng ^{[2
,7
]}

机构：

[1] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Geriatr Med Ctr, Chengdu, Peoples R China

[2] Int Inst Spatial Lifecourse Epidemiol ISLE, Hong Kong, Peoples R China

[3] Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Peoples R China

[4] ThedaCare Reg Med Ctr Appleton, Dept Hosp Med, Appleton, WI USA

[5] Sichuan Univ, West China Sch Publ Hlth, Chengdu, Peoples R China

[6] Sichuan Univ, West China Hosp 4, Chengdu, Peoples R China

[7] Hong Kong Polytech Univ, Dept Land Surveying & Geoinformat, Hong Kong, Peoples R China

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2020年 / 31卷 / 12期

基金：

国家重点研发计划;

关键词：

CLINICAL CHARACTERISTICS; MYOCARDIAL-INFARCTION; CORONAVIRUS; INFECTIONS; PNEUMONIA; OUTCOMES; SARS; WUHAN; ACE2;

D O I：

10.1016/j.tem.2020.10.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Coronavirus disease 2019 (COVID-19) patients with pre-existing cardiovascular disease (CVD) or with cardiovascular complications have a higher risk of mortality. The main cardiovascular complications of COVID-19 include acute cardiac injury, acute myocardial infarction (AMI), myocarditis, arrhythmia, heart failure, shock, and venous thromboembolism (VTE)/pulmonary embolism (PE). COVID-19 can cause cardiovascular complications or deterioration of coexisting CVD through direct or indirect mechanisms, including viral toxicity, dysregulation of the renin-angiotensin-aldosterone system (RAAS), endothelial cell damage and thromboinflammation, cytokine storm, and oxygen supply-demand mismatch. We systematically review cardiovascular manifestations, histopathology, and mechanisms of COVID-19, to help to formulate future research goals and facilitate the development of therapeutic management strategies.

引用

页码：893 / 904

页数：12

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