The effects of ankaferd blood stopper and microporous polysaccharide hemospheres on epidural fibrosis in rat laminectomy model

被引：6

作者：

Ozay, Rafet ^{[1
]}

Yavuz, Osman Yuksel ^{[1
]}

Turkoglu, Mehmet Erhan ^{[1
]}

Aktas, Abit ^{[1
]}

Yigit, Funda ^{[1
]}

Ozdemir, Haci Mustafa ^{[1
]}

Sekerci, Zeki ^{[1
]}

机构：

[1] Istanbul Univ, Fac Vet Med, Dept Histol & Embryol, TR-34320 Avcilar, Turkey

来源：

ACTA CIRURGICA BRASILEIRA | 2015年 / 30卷 / 12期

关键词：

Fibrosis; Laminectomy; Polysaccharides; Hemostasis; Rats; BACK SURGERY SYNDROME; LUMBAR DISKECTOMY; PREVENTION; ADHESIONS; EFFICACY;

D O I：

10.1590/S0102-865020150120000002

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

PURPOSE: To investigate whether topically administered hemostatic agents ankaferd blood stopper and microporous polysaccharide hemospheres can decrease epidural fibrosis after laminectomy in rats. METHODS: Eighteen adult male Sprague-Dawley rats were equally and randomly divided into three groups. In the treatment groups, ankaferd blood stopper and microporous polysaccharide hemospheres topically administrated upon duramater surface after laminectomy. Fibroblast count, epidural fibrosis and arachnoidal involvement were evaluated and graded histopathologically. RESULTS: Our data revealed that the count of fibroblasts, the grading of epidural fibrosis and arachnoideal involvement in the rats treated with microporous polysaccharide hemospheres were significantly less than the control group. Although the arachnoideal involvement in ankaferd blood stopper group were significantly less than the control group, there were no statistical differences when comparing the grading of epidural fibrosis and the fibroblasts count between the treatment groups and the control group. CONCLUSION: The ankaferd blood stopper and microporous polysaccharide hemospheres reduced epidural fibrosis and arachnoideal involvement after laminectomy in rats.

引用

页码：799 / 805

页数：7

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